Cancer Letters
Volume 241, Issue 1 , Pages 79-86 , 8 September 2006

TEL/ARG induces cytoskeletal abnormalities in 293T cells

  • Chiara Palmi

      Affiliations

    • Centro Ricerca Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Grazia Fazio

      Affiliations

    • Centro Ricerca Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Arianna Cassetti

      Affiliations

    • Consorzio M.I.A., Università di Milano-Bicocca, Monza, Italy
    • ,
  • Alessandra Aloisi

      Affiliations

    • Centro Ricerca Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy
    • Dipartimento di Scienze Biomediche, Università di Catania, Catania, Italy
    • ,
  • Antonello Villa

      Affiliations

    • Consorzio M.I.A., Università di Milano-Bicocca, Monza, Italy
    • ,
  • Andrea Biondi

      Affiliations

    • Centro Ricerca Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Giovanni Cazzaniga

      Affiliations

    • Centro Ricerca Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 039 233 2232/3661; fax: +39 039 233.2167.

Received 12 August 2005 ,Revised 4 October 2005 ,Accepted 7 October 2005.

References 

  1. Raimondi SC, Shurtleff SA, Downing JR, Rubnitz J, Mathew S, Hancock M, et al. 2p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia. Blood. 1997;90:4559–4566
  2. Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, et al. A novel human gene closely related to the abl proto-oncogene. Science. 1986;234:1545–1548
  3. Cazzaniga G, Tosi S, Aloisi A, Giudici G, Daniotti M, Pioltelli P, et al. The tyrosine kinase Abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood. 1999;94:4370–4373
  4. Iijima Y, Ito T, Oikawa T, Eguchi M, Eguchi-Ishimae M, Kamada N, et al. A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. Blood. 2000;95:2126–2131
  5. Griesinger F, Janke A, Podleschny M, Bohlander K. Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukemia cell line. Br. J. Haematol. 2002;119:454–458
  6. Van Etten RA, Jackson PK, Baltimore D, Sanders MC, Matsudaira PT, Janmey A. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity. J. Cell Biol. 1994;124:325–340
  7. Moresco EM, Koleske J. Regulation of neuronal morphogenesis and synaptic function by Abl family kinases. Curr. Opin. Neurobiol. 2003;13:535–544
  8. Salgia R, Li JL, Ewaniuk DS, Pear W, Pisick E, Burky SA, et al. BCR-ABL induces multiple abnormalities of cytoskeletal function. J. Clin. Invest. 1997;100:46–57
  9. Cheng K, Kurzrock R, Qiu X, Estrov Z, Ku S, Dulski KM, et al. Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cells. Cancer. 2002;95:440–450
  10. Heisterkamp N, Voncken JW, Senadheera D, Gonzalez-Gomez I, Reichert A, Haataja L, et al. Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants. Blood. 2000;96:2226–2232
  11. Okuda K, Oda A, Sato Y, Nakayama A, Fujita H, Sonoda Y, et al. Signal transduction and cellular functions of the TEL/ARG oncoprotein. Leukemia [Epub ahead of print]. 2005;
  12. Chomczynski P. Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Anal. Biochem. 1987;162:156–159
  13. Kingston RE. Introduction of DNA into mammalian cells. In:  Ausubel FM,  Brent R,  Kingston RE,  Moore DD,  Seidman JG,  Smith JA,  Struhl K editor. Current Protocols in Molecular Biology. New York: Wiley; 1994;p. 9.1.4–9.1.11
  14. Rogozin IB, Milanesi L. Analysis of donor splice sites in different eukaryotic organisms. J. Mol. Evol. 1997;45:50–59
  15. Iijima Y, Okuda K, Tojo A, Tri NK, Setoyama M, Sakaki Y, et al. Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG. Oncogene. 2002;21:4374–4383
  16. Hernandez SE, Settleman J, Koleske J. Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase. Curr. Biol. 2004;14:691–696
  17. Ridley AJ, Self AJ, Kasmi F, Paterson HF, Hall A, Marshall CJ, et al. Rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. Eur. Mol. biol. Org. J. 1993;12:5151–5160
  18. Hu KQ, Settleman J. Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. Eur. Mol. Biol. Org. J. 1997;16:473–483
  19. Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992;70:389–399
  20. Miura Y, Kikuchi A, Musha T, Kuroda S, Yaku H, Sasaki T, et al. Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells. J. Biol. Chem. 1993;268:510–515
  21. Paterson HF, Self AJ, Garrett MD, Just I, Aktories K, Hall A. Microinjection of recombinant p21rho induces rapid changes in cell morphology. J. Cell Biol. 1990;111:1001–1007
  22. Koleske AJ, Gifford AM, Scott ML, Nee M, Bronson RT, Miczek KA, et al. Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron. 1998;21:1259–1272
  23. Wang Y, Miller AL, Mooseker MS, Koleske J. The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin. Pnas. 2001;98:14865–14870
  24. Miller AL, Wang Y, Mooseker MS, Koleske J. The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. J. Cell Biol. 2004;165:407–419
  25. Galkin VE, Orlova A, Koleske AJ, Egelman H. The Arg non-receptor tyrosine kinase modifies F-actin structure. J. Mol. Biol. 2005;346:565–575
  26. Woodring PJ, Hunter T, Wang YJ. Inhibition of c-Abl tyrosine kinase activity by filamentous actin. J. Biol. Chem. 2001;276:27104–27110
  27. Fincham VJ, Chudleigh A, Frame C. Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci. 1999;112:947–956

PII: S0304-3835(05)00911-0

doi: 10.1016/j.canlet.2005.10.017

Cancer Letters
Volume 241, Issue 1 , Pages 79-86 , 8 September 2006

Article Tools

* Image Usage & Resolution