Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts

Gunji, Akemi; Uemura, Akiko; Tsutsumi, Masahiro; Nozaki, Tadashige; Kusuoka, Osamu; Omura, Ken; Suzuki, Hiroshi; Nakagama, Hitoshi; Sugimura, Takashi; Masutani, Mitsuko

doi:10.1016/j.canlet.2005.10.003

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Volume 241, Issue 1 , Pages 87-92, 8 September 2006

Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts

Akemi Gunji
- Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- Department of Oral Surgery, Tokyo Medical and Dental University Graduate School, Bunkyo-ku, Tokyo, Japan
Akiko Uemura
- Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- ADP-ribosylation in Oncology Project, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Masahiro Tsutsumi
- Department of Oncological Pathology, Cancer Center, Nara Medical University, 840, Shijo-cho, Kashihara, Nara 634-8521, Japan
Tadashige Nozaki
- Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Osamu Kusuoka
- Department of Oncological Pathology, Cancer Center, Nara Medical University, 840, Shijo-cho, Kashihara, Nara 634-8521, Japan
Ken Omura
- Department of Oral Surgery, Tokyo Medical and Dental University Graduate School, Bunkyo-ku, Tokyo, Japan
- Department of Advanced Molecular Diagnosis and Maxillofacial Surgery, Hard Tissue Genome Research Center, Tokyo Medical and Dental University
Hiroshi Suzuki
- Chugai Pharmaceutical Co. Ltd. Gotemba, 1-135, Komakado, Gotemba, Shizuoka, 412-0038, Japan
Hitoshi Nakagama
- Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Takashi Sugimura
- Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Mitsuko Masutani
- Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- ADP-ribosylation in Oncology Project, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- Corresponding author. Address: ADP-ribosylation in Oncology Project, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan. Tel.: +81 3 3542 2511x4551; fax: +81 3 3542 2530.