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Cancer Letters
Volume 241, Issue 1
, Pages 31-41
, 8 September 2006
Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells
References
- Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibiton of microglial activation,. J. Neuroimmunol. 2004;148:24–31
- . Immunosuppressive and anti-inflammatory mechanism of triptolide, the principal active diterpenoid from the Chinese medicinal herb tripterygium wilfordii hook. f. Drugs R.D. 2003;4:1–18
- Triptolide: a potential male contraceptive. J. Androl. 1998;19:479–486
- Male antifertility compounds from Tripterygium wilfordii Hook f. Contraception. 1993;47:387–400
- Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii. Cancer Lett. 1997;112:113–117
- . Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. Acta Pharmacol. Sin. 1991;12:406–410
- PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol. Cancer Ther. 2003;2:855–862
- Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells. Oncogene. 2001;20:8009–8018
- . Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin. Cancer Res. 2002;8:2666–2674
- . Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol. Lett. 2001;122:81–87
- . PG490 (triptolide) cooperate with tumor necrosis factor-α to induce apoptosis in tumor cells. J. Biol. Chem. 1999;274:13451–13455
- Triptolide and chemotherapy cooperate in tumor cell apoptosis, a role for the p53 pathway. J. Biol. Chem. 2001;276:2221–2227
- . The role of p53 in chemosensitivity and radiosensitivity. Oncogene. 2000;22:7486–7495
- Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 1997;57:4285–4300
- . Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity. Oncogene. 1998;17:2339–2350
- . The p53 tumor suppressor gene in anticancer agent-induced apoptosis and chemosensitivity of human gastrointestinal cancer cell lines. Cancer Chemother. Pharmacol. 1999;43:43–49
- . Surfing the p53 network. Nature. 2000;408:307–310
- . Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene. 2000;19:1735–1743
- Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000;288:1053–1058
- . BID regulation by p53 contributes to chemosensitivity. Nat. Cell. Biol. 2002;4:842–849
- . Proapoptotic BAX and BAK: a requisite gateway to mitochondria dysfunction and death. Science. 2001;292:727–730
- . Regulation of p53 downstream genes. Semin. Cancer Biol. 1998;8:345–357
- 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell. 1997;1:3–11
- . The Bcl-2 family: regulation of the cellular life-or-death switch. Nat. Rev. Cancer. 2002;2:647–656
- Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res. 1994;54:3253–3259
- . Bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair. Cancer Res. 1993;53:4251–4256
- . Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res. 1995;55:3902–3907
- . Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. Genes Dev. 2003;17:832–837
- Conversion of Bcl-2 to a Bax-like death effector by caspases. Science. 1997;278:1966–1968
- Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. USA. 1994;91:9238–9242
- . Inactivation of Bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. USA. 1995;92:4507–4511
- . Involvement of microtubules in the regulation of Bcl-2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinases. Mol. Cell. Biol. 1998;18:3509–3517
- Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J. Biol. Chem. 1999;274:21155–21161
- . Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release. J. Biol. Chem. 1998;273:1437–1441
- . Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2. Mol. Pharmacol. 2002;61:142–149
- . Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004;23:2838–2849
- . Map kinase signaling pathways and hematologic malignancies. Blood. 2003;101:4667–4679
- . Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes. Oncogene. 1995;11:1947–1953
- P38 alpha Mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol. Biol. Cell. 2004;15:922–933
- . The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light. EMBO J. 1996;15:6552–6563
- PG490-mediated sensitization of lung cancer cells to Apo-2L/TRAIL-induced apoptosis requires action of ERK2. Oncogene. 2003;22:5427–5435
- . Bcl-2 protects HL-60 cells from apoptosis by stabilizing their intracellular calcium pools. Life Sci. 2001;68:2873–2883
- . Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell. Dev. Biol. 1999;15:269–290
- . Induction of apoptosis by bleomycin in p53-null HL-60 leukemia cells. Int. J. Oncol. 2004;24:313–319
- Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. Biochem. Pharmacol. 2003;66:273–280
- . The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J. 1996;15:6979–6990
- . G1 phase-dependent expression of Bcl-2 mRNA and protein correlates with chemoresistance of human cancer cells. Mol. Pharmacol. 2000;58:1001–1010
- Bcl-2 retards cell cycle entry through p27(kip1), pRB, relative p130, and altered E2F regulation. Mol. Cell. Biol. 2000;20:4745–4753
- . Growth factor starvation of Bcl-2 overexpressing murine bone marrow cells induced refractoriness of IL-3 stimulation of proliferation. Oncogene. 1994;9:1117–1122
- Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation. Biochem. Biophys. Res. Commun. 2004;319:980–986
- . Cleavage of Bcl-2 in oxidant-and cisplatin-induced apoptosis of human melanoma cells. Oncogene. 2001;20:4591–4595
- Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage. Blood. 2001;98:3762–3769
- . Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia. 1999;13:719–728
- . Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Differ. 2000;7:227–233
- Induction of apoptosis by enediyne antibiotic calicheamicin thetaII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner. Oncogene. 2003;22:9107–9120
- . Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphate-1 in lipopolysaccharide-stimulated macrophages,. J. Immunol. 2002;169:6408–6416
PII: S0304-3835(05)00874-8
doi: 10.1016/j.canlet.2005.10.001
© 2005 Elsevier Ireland Ltd. All rights reserved.
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Cancer Letters
Volume 241, Issue 1
, Pages 31-41
, 8 September 2006
