Cancer Letters
Volume 238, Issue 2 , Pages 240-247 , 18 July 2006

Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma

  • Siv Kjølsrud Bøhn

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, Blindern N-0316, Oslo, Norway
    • These authors contributed equally to this work.
    • ,
  • Sigbjørn Smeland

      Affiliations

    • Norwegian Radium Hospital, Montebello, Oslo, Norway
    • These authors contributed equally to this work.
    • ,
  • Amrit Kaur Sakhi

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, Blindern N-0316, Oslo, Norway
    • These authors contributed equally to this work.
    • ,
  • Magne Thoresen

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, Blindern N-0316, Oslo, Norway
    • ,
  • Kjell Magne Russnes

      Affiliations

    • Norwegian Radium Hospital, Montebello, Oslo, Norway
    • ,
  • Johan Tausjø

      Affiliations

    • Norwegian Radium Hospital, Montebello, Oslo, Norway
    • ,
  • Arne Svilaas

      Affiliations

    • Medical Department, Lipid Clinic, Rikshospitalet, Oslo, Norway
    • ,
  • Tone Svilaas

      Affiliations

    • Medical Department, Lipid Clinic, Rikshospitalet, Oslo, Norway
    • ,
  • Rune Blomhoff

      Affiliations

    • Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, Blindern N-0316, Oslo, Norway
    • Corresponding Author InformationCorresponding author. Tel.: +47 22 85 13 95; fax: +47 22 85 13 96.

Received 28 February 2005 ,Revised 8 July 2005 ,Accepted 10 July 2005.

References 

  1. Cooper CE, Patel RP, Brookes PS, Darley-Usmar VM. Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species. Trends Biochem. Sci. 2002;27:489–492
  2. Deplancke B, Gaskins HR. Redox control of the transsulfuration and glutathione biosynthesis pathways. Curr. Opin. Clin. Nutr. Metab. Care. 2002;5:85–92
  3. Dickinson DA, Forman HJ. Cellular glutathione and thiols metabolism. Biochem. Pharmacol. 2002;64:1019–1026
  4. Sies H. Glutathione and its role in cellular functions. Free Radic. Biol. Med. 1999;27:916–921
  5. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 2001;30:1191–1212
  6. Sheehan D, Meade G, Foley VM, Dowd CA. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem. J. 2001;360:1–16
  7. Keppler D. Export pumps for glutathione S-conjugates. Free Radic. Biol. Med. 1999;27:985–991
  8. Nordberg J, Arner AS. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 2001;31:1287–1312
  9. Wild AC, Mulcahy RT. Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses. Free Radic. Res. 2000;32:281–301
  10. Hayes JD, McLellan LJ. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic. Res. 1999;31:273–300
  11. Whitfield JB. Gamma glutamyl transferase. Crit. Rev. Clin. Lab. Sci. 2001;38:263–355
  12. Therond P, Bonnefont-Rousselot D, Davit-Spraul A, Conti M, Legrand A. Biomarkers of oxidative stress: an analytical approach. Curr. Opin. Clin. Nutr. Metab. Care. 2000;3:373–384
  13. Nuttall SL, Martin U, Sinclair AJ, Kendall MJ. Glutathione: in sickness and in health. Lancet. 1998;351:645–646
  14. Jones DP, Carlson JL, Samiec PS, et al. Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC. Clin. Chim. Acta. 1998;275:175–184
  15. Lang CA, Mills BJ, Mastropaolo W, Liu MC. Blood glutathione decreases in chronic diseases. J. Lab. Clin. Med. 2000;135:402–405
  16. Seidman MD, Quirk WS, Shirwany NA. Reactive oxygen metabolites, antioxidants and head and neck cancer. Head. Neck. 1999;21:467–479
  17. Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur. J. Cancer Prev. 1998;7:9–16
  18. Tatebe S, Unate H, Sinicrope FA, et al. Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma- GCSh) in human colorectal carcinoma. Int. J. Cancer. 2002;97:21–27
  19. Stanulla M, Schrappe M, Brechlin A,M, Zimmermann M, Welte K. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Blood. 2000;95:1222–1228
  20. Davies SM, Robison LL, Buckley JD, et al. Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia. J. Clin. Oncol. 2001;19:1279–1287
  21. Kearns PR, Pieters R, Rottier MM, Pearson AD, Hall AG. Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood. 2001;97:393–398
  22. Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 1994;65:27–33
  23. Ladner RD. The role of dUTPase and uracil-DNA repair in cancer chemotherapy. Curr. Protein Pept. Sci. 2001;2:361–370
  24. Brahme A, Nilsson J, Belkic D. Biologically optimized radiation therapy. Acta. Oncol. 2001;40:725–734
  25. Sturgis EM, Wei Q. Genetic susceptibility–molecular epidemiology of head and neck cancer. Curr. Opin. Oncol. 2002;14:310–317
  26. Bailey SM. A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction. Free Radic. Res. 2003;37:585–596
  27. Mork J, Lie AK, Glattre E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 2001;344:1125–1131
  28. Geisler SA, Olshan AF. GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review. Am. J. Epidemiol. 2001;154:95–105
  29. Droge W, Eck HP, Mihm S. HIV-induced cysteine deficiency and T-cell dysfunction–a rationale for treatment with N-acetylcysteine. Immunol. Today. 1992;13:211–214
  30. Yim CY, Hibbs JB, McGregor JR, Galinsky RE, Samlowski WE. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J. Immunol. 1994;152:5796–5805
  31. Hargrove ME, Wang J, Ting CC. Regulation by glutathione of the activation and differentiation of IL-4-dependent activated killer cells. Cell. Immunol. 1993;149:433–443
  32. Iwata S, Hori T, Sato N, et al. Thiol-mediated redox regulation of lymphocyte proliferation. Possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression. J. Immunol. 1994;152:5633–5642
  33. Chen G, Wang SH, Converse CA. Glutathione increases interleukin-2 production in human lymphocytes. Int. J. Immunopharmacol. 1994;16:755–760
  34. Jeannin P, Delneste Y, Lecoanet-Henchoz S, et al. Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis. J. Exp. Med. 1995;182:1785–1792
  35. Tsuyuki S, Yamauchi A, Nakamura H, et al. Possible availability of N-acetylcysteine as an adjunct to cytokine therapy for hepatocellular carcinoma. Clin. Immunol. Immunopathol. 1998;88:192–198
  36. Tsuyuki S, Yamauchi A, Nakamura H, et al. N-acetylcysteine improves cytotoxic activity of cirrhotic rat liver-associated mononuclear cells. Int. Immunol. 1998;10:1501–1508
  37. Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. FASEB J. 1998;95:3071–3076
  38. Kinscherf R, Fischbach T, Mihm S, et al. Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells. FASEB J. 1994;8:448–451
  39. Whiteside TL, Vujanovic NL, Herberman RB. Natural killer cells and tumor therapy. Curr. Top. Microbiol. Immunol. 1998;230:221–244
  40. Staal FJ, Roederer M, Israelski DM, et al. Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals, AIDS Res. Hum. Retroviruses. 1992;8:305–311
  41. Herzenberg LA, De Rosa SC, Dubs JG, et al. Glutathione deficiency is associated with impaired survival in HIV disease. FASEB J. 1997;94:1967–1972
  42. Muller F, Svardal AM, Nordoy I, Berge RK, Aukrust P, Froland SS. Virological and immunological effects of antioxidant treatment in patients with HIV infection. Eur. J. Clin. Invest. 2000;30:905–914
  43. De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur. J. Clin. Invest. 2000;30:915–929
  44. Breitkreutz R, Pittack N, Nebe CT, et al. Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials. J. Mol. Med. 2000;78:55–62
  45. Kojima S, Ishida H, Takahashi M, Yamaoka K. Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity. Radiat. Res. 2002;157:275–280
  46. Jones DP. Redox potential of GSH/GSSG couple: assay and biological significance. Meth. Enzymol. 2002;348:93–112
  47. Ono H, Sakamoto A, Sakura N. Plasma total glutathione concentrations in epileptic patients taking anticonvulsants. Clin. Chim. Acta. 2000;298:135–143
  48. Jones DP, Carlson JL, Mody VC, Cai J, Lynn MJ, Sternberg P. Redox state of glutathione in human plasma. Free Radic. Biol. Med. 2000;28:625–635
  49. Jadhav GK, Bhanumathi P, Uma DP, et al. Possible role of glutathione in predicting radiotherapy response of cervix cancer. Int. J. Radiat. Oncol. Biol. Phys. 1998;41:3–5
  50. Bhuvarahamurthy V, Balasubramanian N, Govindasamy S. Effect of radiotherapy and chemoradiotherapy on circulating antioxidant system of human uterine cervical carcinoma. Mol. Cell. Biochem. 1996;158:17–23

PII: S0304-3835(05)00667-1

doi: 10.1016/j.canlet.2005.07.027

Cancer Letters
Volume 238, Issue 2 , Pages 240-247 , 18 July 2006

Article Tools

* Image Usage & Resolution