Cancer Letters
Volume 238, Issue 2 , Pages 224-229, 18 July 2006

Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma

  • Ivana Grbesa

      Affiliations

    • Laboratory of Molecular Pathology, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka cesta 54, 10002 Zagreb, Croatia
    • ,
  • Mirko Ivkic

      Affiliations

    • Department of Otorhinolaryngology and Head and Neck Surgery, Sestre Milosrdnice University Hospital, 10000 Zagreb, Croatia
    • ,
  • Boris Pegan

      Affiliations

    • Department of Otorhinolaryngology and Head and Neck Surgery, Sestre Milosrdnice University Hospital, 10000 Zagreb, Croatia
    • ,
  • Koraljka Gall-Troselj

      Affiliations

    • Laboratory of Molecular Pathology, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka cesta 54, 10002 Zagreb, Croatia
    • Corresponding Author InformationCorresponding author. Tel.: +385 1 456 0972; fax: +385 1 468 0119.

Received 9 May 2005; received in revised form 7 July 2005; accepted 8 July 2005.

Abstract 

The gene for insulin-like growth factor two, IGF2 is maternally imprinted. Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 promoter usage was active in eight LSCCs, among them four with LOI. As it was activated in four tumors with maintenance of imprinting (MOI) and four non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 LOI in LSCC.

Keywords: IGF2, Laryngeal squamous cell carcinoma, Imprinting, Promoter usage

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PII: S0304-3835(05)00659-2

doi:10.1016/j.canlet.2005.07.003

Cancer Letters
Volume 238, Issue 2 , Pages 224-229, 18 July 2006

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