Cancer Letters
Volume 238, Issue 2 , Pages 188-196, 18 July 2006

Altered iron metabolism, transferrin receptor 1 and ferritin in patients with colon cancer

  • Maja Prutki

      Affiliations

    • University of Zagreb, Medical School, Zagreb, Croatia
    • ,
  • Marija Poljak-Blazi

      Affiliations

    • Laboratory for Oxidative Stress, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, Croatia
    • ,
  • Marko Jakopovic

      Affiliations

    • University of Zagreb, Medical School, Zagreb, Croatia
    • ,
  • Davor Tomas

      Affiliations

    • Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia
    • ,
  • Igor Stipancic

      Affiliations

    • Dubrava University Hospital, Zagreb, Croatia
    • ,
  • Neven Zarkovic

      Affiliations

    • Laboratory for Oxidative Stress, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, Croatia
    • Corresponding Author InformationCorresponding author. Tel.: +385 1 4560 937; fax: +385 1 4561 010.

Received 27 April 2005; received in revised form 1 July 2005; accepted 4 July 2005.

Abstract 

In this study, the level and distribution of transferrin receptor 1 (TfR1) and ferritin in colorectal carcinoma and in normal colon epithelium has been determined relative to the tumor stage and iron status of patients using immunohistochemical staining methods. While the majority of carcinoma patients were anemic, no relationship between the level of colon tissue ferritin and TfR1 and the systemic parameters of iron metabolism was evident. Furthermore, no association between ferritin content and the grade of colorectal carcinoma was observed. However, a relationship between the expression of TfR1 and the grade of colorectal carcinoma was observed. In this case high expression of TfR1 was found in colorectal carcinoma samples of Dukes A or B grade, and well differentiated colorectal carcinoma cells. In comparison, weak or no expression of TfR1 was observed in carcinoma samples of Dukes C or D grade with poorly differentiated cells and in carcinoma samples that had lymph node infiltration and distant metastasis.

Keywords: Colon carcinoma, Transferrin receptor 1, Ferritin, Iron metabolism, Metastasis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0304-3835(05)00656-7

doi:10.1016/j.canlet.2005.07.001

Cancer Letters
Volume 238, Issue 2 , Pages 188-196, 18 July 2006

Article Tools

* Image Usage & Resolution