Cancer Letters
Volume 238, Issue 2 , Pages 161-167, 18 July 2006

The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation

  • Ester M. Hammond
    • ,
  • Rachel A. Freiberg
    • ,
  • Amato J. Giaccia

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: Stanford University School of Medicine, Radiation Oncology, CCSR South Room 1250, 269 Campus Drive, Stanford CA 94305, USA. Tel.: +1 650 725 6418; fax: +1 650 723 7382.

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University, Stanford, California 94303-5152, USA

Received 3 June 2005; accepted 15 June 2005.

Abstract 

Both Chk 1 and Chk 2 are critically important checkpoint kinases. Chk 1 is an essential gene that is required for normal cell division and Chk 2 has been found to be mutated in an ever-growing list of human malignancies. Our recent studies indicate that both Chk 1 and Chk 2 have roles to play in the physiological stress of hypoxia/reoxygenation. Loss or inhibition of either kinase sensitizes cells to hypoxia/reoxygenation indicating that either or both could represent significant therapeutic targets.

Keywords: Hypoxia, Reoxygenation, Chk 1, Chk 2

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PII: S0304-3835(05)00566-5

doi:10.1016/j.canlet.2005.06.029

Cancer Letters
Volume 238, Issue 2 , Pages 161-167, 18 July 2006

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