Polymorphism of glutathione S-transferase Omega gene and risk of cancer

Marahatta, Sujan Babu; Punyarit, Phaibul; Bhudisawasdi, Vajarabhongsa; Paupairoj, Anucha; Wongkham, Sopit; Petmitr, Songsak

doi:10.1016/j.canlet.2005.05.020

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Volume 236, Issue 2 , Pages 276-281, 18 May 2006

Polymorphism of glutathione S-transferase Omega gene and risk of cancer

Sujan Babu Marahatta
- Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
Phaibul Punyarit
- Department of Pathology, Pramongkutklao College of Medicine, Bangkok, Thailand
Vajarabhongsa Bhudisawasdi
- Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Anucha Paupairoj
- Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Sopit Wongkham
- Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Songsak Petmitr
- Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
- Corresponding author. Tel.: +662 3549100x1581; fax: +662 6447934.

Received 21 March 2005; received in revised form 15 May 2005; accepted 17 May 2005.

Abstract

Polymorphic glutathione S-transferase (GST) genes causing variations in enzyme activity may influence individual susceptibility to cancer. Though polymorphisms have been reported in GSTO1 and GSTO2, their predisposition to cancer risk has not yet been explored. In this case control study, 28 cases of hepatocellular carcinoma, 30 cases of cholangiocarcinoma, 31 cases of colorectal cancer, 30 cases of breast cancer and 98 controls were compared for frequencies of GSTO1 and GSTO2 genotypes. The statistical analysis provided the support for the difference in genotypic distribution for GSTO1*A140D between hepatocellular carcinoma (OR 23.83, CI 95%: 5.07–127), cholangiocarcinoma (OR 8.5, CI 95%: 2.07–37.85), breast cancer (OR 3.71, CI 95%: 1.09–13.02) and control. With regards to GSTO2*N140D polymorphism, there was no difference in genotypic distribution between all the types of cancer and control. The study suggests that GSTO1*A140D polymorphism could play an important role as a risk factor for the development of hepatocellular carcinoma, cholangiocarcinoma and breast cancer.

Keywords: Glutathione S-transferase Omega, Polymorphism, Cancer