Cancer Letters
Volume 236, Issue 2 , Pages 282-291 , 18 May 2006

In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells

  • Katarzyna Skupień

      Affiliations

    • Department of Processing and Storage of Plant Raw Materials, Agricultural Academy of Szczecin, 17 Słowackiego st, 71-434 Szczecin, Poland
    • ,
  • Jan Oszmiański

      Affiliations

    • Department of Fruit, Vegetable and Cereal Technology, Agricultural Academy of Wrocław, 25 C.K. Norwida st, 50-375 Wrocław, Poland
    • ,
  • Dorota Kostrzewa-Nowak

      Affiliations

    • Department of Biochemistry, University of Szczecin, 3a Felczaka st, 71-412 Szczecin, Poland
    • ,
  • Jolanta Tarasiuk

      Affiliations

    • Department of Biochemistry, University of Szczecin, 3a Felczaka st, 71-412 Szczecin, Poland
    • Corresponding Author InformationCorresponding author. Tel.: +48 91 444 15 51; fax: +48 91 444 15 50.

Received 6 March 2005 ,Revised 15 May 2005 ,Accepted 17 May 2005.

References 

  1. Hollman PCH, Hertog MGL, Katan MB. Analysis and health effects of flavonoids. Food Chem. 1996;57:43–46
  2. Sauvaget C, Kasagi F, Waldren CA. Dietary factors and cancer mortality among atomic-bomb survivors. Mutat. Res. 2004;551:145–152
  3. Häkkinen S, Heinonen M, Kärenlampi S, Mykkänen H, Ruuskanen J, Törrönen R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 1999;32:345–353
  4. Velioglu YS, Mazza G, Gao L, Oomah BD. Antioxidant activity and total phenolics content in selected fruits, vegetables, and grain products. J. Agric. Food Chem. 1998;46:4113–4117
  5. Kaur C, Kapoor HC. Antioxidants in fruits and vegetables—the millenium's health. Int. J. Food Sci. Technol. 2001;36:703–725
  6. Hibasami H, Esaki H, Kataoka T, Takaue S, Kawakishi S. Human stomach cancer cells undergo apoptosis by genistein, but not other genistein- and daidzein-related compounds. J. Herbs, Spices Med. Plants. 2003;10:39–48
  7. Uesato S, Kitagawa Y, Kamishimoto M, Kumagai A, Hori H, Nagasawa H. Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells. Cancer Lett. 2001;170:41–44
  8. Hibasami H, Jin ZX, Yoshioka K, Ina K, Ohnishi K. Human colon cancer cells undergo apoptosis by theaflavin digallate, epigallocatechin gallate, and oolong tea polyphenol extract. J. Herbs, Spices Med. Plants. 2003;10:29–38
  9. Saleem A, Husheem M, Härkönen P, Pihlaja K. Inhibition of cancer cell growth by crude extract and phenolics of Terminalia chebula retz. Fruit, J. Ethnopharm. 2002;81:327–336
  10. Hannum SM. Potential impact of strawberries on human health: a review of the science. Crit. Rev. Sci. Nutr. 2004;44:1–17
  11. Aherne SA, O'Brien NM. Dietary flavonols: chemistry, food content, and metabolism. Nutrition. 2002;18:75–81
  12. Meyer AS, Heinonen M, Frankel EN. Antioxidant interactions of catechin, cyanidin, caffeic acid, quercetin, and ellagic acid on human LDL oxidation. Food Chem. 1998;61:71–75
  13. Maas JL, Galletta GJ. Ellagic acid, an anticarcinogen in fruits, especially in strawberries: a review. HortScience. 1991;26:10–14
  14. Narayanann AA, Geoffroy O, Willingham MC, Re GG, Nixon DW. p35/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999;136:215–221
  15. Gupta S, Afaq F, Mukhtar H. Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochem. Biophys. Res. Commun. 2001;287:9414–9920
  16. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur. J. Cancer. 1999;35:1517–1525
  17. Kang TB, Liang NC. Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem. Pharmacol. 1997;54:1013–1018
  18. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 1993;62:385–427
  19. Germann UA. P-Glycoprotein–a mediator of multidrug resistance in tumour cells. Eur. J. Cancer. 1996;32:927–944
  20. Marie JP, Zhou DC, Gurbuxani S, Legrand O, Zittoun R. MDR1/P-glycoprotein in haematological neoplasms. Eur. J. Cancer. 1996;32A:1034–1038
  21. Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J. Natl Cancer Inst. 2000;92:1295–1302
  22. Versantvoort CH, Schuurhuis GJ, Pinedo HM, Eekman CA, Kuiper CM, Lankelma J, et al. Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. Br. J. Cancer. 1993;68:939–946
  23. Zhu A, Wang X, Guo Z. Study of tea polyphenol as a reversal agent for carcinoma cell lines' multidrug resistance (study of TP as a MDR reversal agent). Nucl. Med. Biol. 2001;28:735–740
  24. Mei Y, Qian F, Wei D, Liu J. Reversal of cancer multidrug resistance by green tea polyphenols. J. Pharm. Pharmacol. 2004;56:1307–1314
  25. Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract. Cancer Chemother. Pharmacol. 2004;54:525–530
  26. Fernandes J, Castilho RO, da Costa MR, Wagner-Souza K, Coelho Kaplan MA, Gattass CR. Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxicity on multidrug resistant and sensitive leukemia cell lines. Cancer Lett. 2003;20:165–169
  27. Lei F, Xing DM, Xiang L, Zhao YN, Wang W, Zhang LJ, et al. Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract. J. Chromatogr. B. 2003;796:189–194
  28. Xu Y, Deng JZ, Ma J, Chen SN, Marshall R, Jones SH, et al. DNA damaging activity of ellagic acid derivatives. Bioorg. Med. Chem. 2003;11:1593–1596
  29. Maas JL, Wang SY, Galletta GJ. Evaluation of strawberry cultivars for ellagic acid content. HortScience. 1991;26:66–68
  30. Skupień K, Oszmiański J. Comparison of six cultivars of strawberries (Fragaria x ananassa Duch.) grown in northwest Poland. Eur. Food Res. Technol. 2004;219:66–70
  31. Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J. Agric. Food Chem. 2000;48:140–146
  32. McGrath T, Latoud C, Arnold ST, Safa AR, Felsted RL, Center MS. Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression. Biochem. Pharmacol. 1989;38:3611–3619
  33. Marsh W, Sicher D, Center MS. Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug. Cancer Res. 1986;46:4053–4057
  34. Krishnamachary N, Center MS. The MRP gene associated with a non- P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res. 1993;53:3658–3661
  35. Chaudhary PM, Roninson LB. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl Cancer Inst. 1993;85:632–639
  36. Mankhetkorn S, Dubru F, Hesschenbrouck J, Fiallo M, Garnier-Suillerot A. Relation among the resistance factor, kinetics of uptake, and kinetics of the P-glycoprotein-mediated efflux of doxorubicin, daunorubicin, 8-(S)-fluoroidarubicin, and idarubicin in multidrug-resistant K562 cells. Mol. Pharmacol. 1996;49:532–539
  37. Stefanska B, Dzieduszycka M, Bontemps-Gracz M, Borowski E, Martelli S, Supino R, et al. 8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug resistant cell lines. Synthesis and antitumor evaluation. J. Med. Chem. 1999;42:3494–3501
  38. Antonini I, Cola D, Polucci P, Bontemps-Gracz M, Borowski E, Martelli S. Synthesis of (dialkylamino)alkyl-disubstituted pyrimido[5,6,1-de]acridines, a novel group of anticancer agents active on a multidrug resistant cell line. J. Med. Chem. 1995;38:3282–3286
  39. Tarasiuk J, Stefanska B, Plodzich I, Tkaczyk-Gobis K, Seksek O, Martelli S, et al. Anthrapyridones, a novel group of antitumour non-cross resistant anthraquinone analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells. Br. J. Pharmacol. 2002;135:1513–1523
  40. Robert J, Jarry C. Multidrug resistance reversal agents. J. Med. Chem. 2003;46:4805–4817
  41. Sun J, Chu YF, Wu X, Liu RH. Antioxidant and antiproliferative activities of common fruits. J. Agric. Chem. 2002;50:7449–7454
  42. Meyers KJ, Watkins CB, Pritts MP, Liu RH. Antioxidant and antiproliferative activities of strawberries. J. Agric. Food Chem. 2003;51:6887–6892
  43. Ueno I, Nakano N, Hirono I. Metabolic fate of [14C] quercetin in the ACI rat. Jpn. J. Exp. Med. 1983;53:41–50
  44. Donovan JL, Crespy V, Manach C, Morand C, Besson C, Scalbert A, et al. Catechin is metabolized by both the small intestine and liver of rats. J. Nutr. 2001;131:1753–1757
  45. Aherne SA, O'Brien NM. Dietary flavonols: chemistry, food content, and metabolism. Nutrition. 2002;18:75–81
  46. Gee JM, DuPont MS, Day AJ, Plumb GW, Williamson G, Johnson IT. Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J. Nutr. 2000;130:2765–2771
  47. Scalber A, Williamson G. Dietary intake and bioavailability of polyphenols.. J. Nutr. 2000;130:2073S–20085S
  48. Lei F, Xing DM, Xiang L, Zhao YN, Wang W, Zhang LJ, et al. Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract. J. Chromatogr. B. 2003;796:189–194
  49. D. Kostrzewa-Nowak, M.J.I. Paine, C.R. Wolf, J. Tarasiuk, The role of bioreductive activation of doxorubicin in its cytotoxic activity against leukaemia HL60 sensitive cell line and their multidrug resistant sublines. Br. J. Cancer 93 (2005) 89–97.
  50. Tarasiuk J, Kostrzewa-Nowak D, Paine MJI, Wolf CR. The role of bioreductive activation of antitumour drugs, doxorubicin and mitoxantrone, in the cytotoxic activity against leukaemia HL60 senstitive cell line and its multidrug resistant sublines. Seventh International Conference on Anticancer Research, Corfu, Greece. October 25–30, 2004. Anticancer Res. 2004;(2004):3647–3648
  51. Mertens-Talcott SU, Percival SS. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 2005;218:141–151
  52. Mertens-Talcott SU, Talcott ST, Percival SS. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J. Nutr. 2003;133:2669–2674

PII: S0304-3835(05)00498-2

doi: 10.1016/j.canlet.2005.05.018

Cancer Letters
Volume 236, Issue 2 , Pages 282-291 , 18 May 2006

Article Tools

* Image Usage & Resolution