Cancer Letters
Volume 229, Issue 1 , Pages 93-99 , 8 November 2005

HPV 16 E6 sequence variations in Indian patients with cervical neoplasia

  • Narayanan Sathish

      Affiliations

    • Department of Clinical Virology, Christian Medical College, Vellore 632004, India
    • ,
  • Priya Abraham

      Affiliations

    • Department of Clinical Virology, Christian Medical College, Vellore 632004, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 416 2282772; fax: +91 416 2232035.
    • ,
  • Abraham Peedicayil

      Affiliations

    • Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, India
    • ,
  • Gopalan Sridharan

      Affiliations

    • Department of Clinical Virology, Christian Medical College, Vellore 632004, India
    • ,
  • George Chandy

      Affiliations

    • Department of Clinical Gastroenterology and Hepatology, Christian Medical College, Vellore, India

Received 24 March 2005 ,Revised 15 April 2005 ,Accepted 20 April 2005.

References 

  1. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 1993;75:495–505
  2. Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 1989;243:934–937
  3. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl Acad. Sci. USA. 1992;89:4549–4553
  4. Smotkin D, Wettstein FO. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl Acad. Sci. USA. 1986;83:4680–4684
  5. Smotkin D, Prokoph H, Wettstein FO. Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms. J. Virol. 1989;63:1441–1447
  6. Stoppler MC, Ching K, Stoppler H, Clancy K, Schlegel R, Icenogle J. Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. J. Virol. 1996;70:6987–6993
  7. Kirnbauer R, Taub J, Greenstone H, Roden R, Durst M, Gissmann L, et al. Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J. Virol. 1993;67:6929–6936
  8. Ellis JR, Keating PJ, Baird J, Hounsell EF, Renouf DV, Rowe M, et al. The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer. Nat. Med. 1995;1:464–470
  9. Yamada T, Wheeler CM, Halpern AL, Stewart AC, Hildesheim A, Jenison SA. Human papillomavirus type 16 variant lineages in United States populations characterized by nucleotide sequence analysis of the E6, L2, and L1 coding segments. J. Virol. 1995;69:7743–7753
  10. Yamada T, Manos MM, Peto J, Greer CE, Munoz N, Bosch FX, et al. Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J. Virol. 1997;71:2463–2472
  11. Crook T, Tidy JA, Vousden KH. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell. 1991;67:547–556
  12. Kast WM, Brandt RM, Sidney J, Drijfhout JW, Kubo RT, Grey HM, et al. Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J. Immunol. 1994;152:3904–3912
  13. Zehbe I, Wilander E, Delius H, Tommasino M. Human papillomavirus 16 E6 variants are more prevalent in invasive cervical carcinoma than the prototype. Cancer Res. 1998;58:829–833
  14. Kammer C, Tommasino M, Syrjanen S, Delius H, Hebling U, Warthorst U, et al. Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease. Br. J. Cancer. 2002;86:269–273
  15. Pillai MR, Sreevidya S, Pollock BH, Jayaprakash PG, Herman B. Human papillomavirus type 16 E6 and E7 gene variations in Indian cervical cancer. Gynecol. Oncol. 2002;87:268–273
  16. Picconi MA, Alonio LV, Sichero L, Mbayed V, Villa LL, Gronda J, et al. Human papillomavirus type-16 variants in Quechua aboriginals from Argentina. J. Med. Virol. 2003;69:546–552
  17. del Refugio Gonzalez-Losa M, Laviada Mier y Teran MA, Puerto-Solis M, Garcia-Carranca A. Molecular variants of HPV type 16 E6 among Mexican women with LSIL and invasive cancer. J. Clin. Virol. 2004;29:95–98
  18. Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlee F, Hildesheim A, et al. Improved amplification of genital human papillomaviruses. J. Clin. Microbiol. 2000;38:357–361
  19. Sotlar K, Selinka HC, Menton M, Kandolf R, Bultmann B. Detection of human papillomavirus type 16 E6/E7 oncogene transcripts in dysplastic and nondysplastic cervical scrapes by nested RT-PCR. Gynecol. Oncol. 1998;69:114–121
  20. Stephen AL, Thompson CH, Tattersall MH, Cossart YE, Rose BR. Analysis of mutations in the URR and E6/E7 oncogenes of HPV 16 cervical cancer isolates from central China. Int. J. Cancer. 2000;86:695–701
  21. Chan PK, Lam CW, Cheung TH, Li WW, Lo KW, Chan MY, et al. Human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern China. J. Infect. Dis. 2002;186:696–700
  22. Chan SY, Ho L, Ong CK, Chow V, Drescher B, Durst M, et al. Molecular variants of human papillomavirus type 16 from four continents suggest ancient pandemic spread of the virus and its coevolution with humankind. J. Virol. 1992;66:2057–2066
  23. Tornesello ML, Duraturo ML, Salatiello I, Buonaguro L, Losito S, Botti G, et al. Analysis of human papillomavirus type-16 variants in Italian women with cervical intraepithelial neoplasia and cervical cancer. J. Med. Virol. 2004;74:117–126
  24. Zehbe I, Mytilineos J, Wikstrom I, Henriksen R, Edler L, Tommasino M. Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women. Hum. Immunol. 2003;64:538–542

PII: S0304-3835(05)00452-0

doi: 10.1016/j.canlet.2005.04.026

Cancer Letters
Volume 229, Issue 1 , Pages 93-99 , 8 November 2005

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