GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer

Hansen, Rikke; Sæbø, Mona; Skjelbred, Camilla Furu; Nexø, Bjørn Andersen; Hagen, Per Christian; Bock, Günther; Bowitz Lothe, Inger Marie; Johnson, Egil; Aase, Steinar; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H.

doi:10.1016/j.canlet.2005.04.019

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Volume 229, Issue 1 , Pages 85-91, 8 November 2005

GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer

Rikke Hansen
- National Institute of Occupational Health, Copenhagen, Denmark
Mona Sæbø
- Department of Environmental and Health Studies, Faculty of Arts and Sciences, Telemark University College, Hallvard Eikas plass, Bø i Telemark N-3800, Norway
- Mona Sæbø and Camilla Furu Skjelbred have contributed equally.
Camilla Furu Skjelbred
- Department of Environmental and Health Studies, Faculty of Arts and Sciences, Telemark University College, Hallvard Eikas plass, Bø i Telemark N-3800, Norway
- Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway
- Mona Sæbø and Camilla Furu Skjelbred have contributed equally.
Bjørn Andersen Nexø
- Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
Per Christian Hagen
- Department of Environmental and Health Studies, Faculty of Arts and Sciences, Telemark University College, Hallvard Eikas plass, Bø i Telemark N-3800, Norway
Günther Bock
- Department of Surgery, Telemark Hospital, Skien, Norway
Inger Marie Bowitz Lothe
- Department of Pathology, Ullevaal University Hospital, Oslo, Norway
Egil Johnson
- Department of Gastroenterological Surgery, Ullevaal University Hospital, Oslo, Norway
Steinar Aase
- Department of Pathology, The Gade Institute, Haukeland University Hospital, N-5021 Bergen, Norway
Inger-Lise Hansteen
- Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway
Ulla Vogel
- National Institute of Occupational Health, Copenhagen, Denmark
Elin H. Kure
- Department of Environmental and Health Studies, Faculty of Arts and Sciences, Telemark University College, Hallvard Eikas plass, Bø i Telemark N-3800, Norway
- Department of Pathology, Ullevaal University Hospital, Oslo, Norway
- Corresponding author. Address: Department of Environmental and Health Studies, Faculty of Arts and Sciences, Telemark University College, Hallvard Eikas plass, Bø i Telemark N-3800, Norway. Tel.: +47 3595 2500; fax: +47 3595 2703.

Received 20 February 2005; received in revised form 10 April 2005; accepted 15 April 2005.

Abstract

Little is known about genetic risk factors for colorectal cancer. We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas. We studied 166 cases with adenocarcinoma, 974 with adenomas and 397 controls recruited from the Norwegian cohort NORCCAP. No associations were found between the polymorphism GPX Pro¹⁹⁸Leu and risk of colorectal adenomas or carcinomas. Carriers of the variant allele OGG1 Ser³²⁶Cys polymorphism had a lowered risk of colorectal cancer, OR=0.56 (95% confidence interval 0.33–0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma.

Keywords: Dysplasia, Oxidative stress, Population based, Carcinoma