A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection

Zhu, Zhong-Zheng; Cong, Wen-Ming; Liu, Shu-Fang; Xian, Zhi-Hong; Wu, Wei-Qing; Wu, Meng-Chao; Gao, Bin; Hou, Li-Fang; Zhu, Guan-Shan

doi:10.1016/j.canlet.2005.04.014

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Volume 229, Issue 1 , Pages 77-83, 8 November 2005

A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection

Zhong-Zheng Zhu
- Department of Pathology, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, 200438 Shanghai, People's Republic of China
Wen-Ming Cong
- Department of Pathology, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, 200438 Shanghai, People's Republic of China
- Corresponding author. Tel./fax: +86 21 25070854.
Shu-Fang Liu
- Department of Gastroenterology, Railway Hospital, Tongji University, 200072 Shanghai, People's Republic of China
Zhi-Hong Xian
- Department of Pathology, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, 200438 Shanghai, People's Republic of China
Wei-Qing Wu
- Department of Pathology, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, 200438 Shanghai, People's Republic of China
Meng-Chao Wu
- Department of Pathology, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, 200438 Shanghai, People's Republic of China
Bin Gao
- National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20852, USA
Li-Fang Hou
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Guan-Shan Zhu
- National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20852, USA
- Department of Infectious Diseases, Changhai Hospital, 200433 Shanghai, People's Republic of China

Received 31 January 2005; received in revised form 8 April 2005; accepted 11 April 2005.

Abstract

To clarify the modifying effect of the codon 72 p53 polymorphism on hepatocellular carcinoma (HCC) stratified by chronic hepatitis B virus (HBV) infection status, 111 incident cases of HCC and 424 controls in HBV-negative subjects and 135 cases and 125 controls in HBV-positive subjects were identified. No correlation between the polymorphism and HCC risk was found when comparing the HBV-positive cases to controls. However, in HBV-negative subjects, Arg/Pro and Pro/Pro genotypes had a 1.97-fold and a 3.36-fold increased risk for HCC, respectively. In subjects with the Pro allele and family history of HCC yielded an 11.81-fold increased risk of HCC.

Keywords: p53, Hepatitis B virus, DNA polymorphisms, Hepatocellular carcinoma