Cancer Letters
Volume 228, Issue 1 , Pages 37-41 , 18 October 2005

DNA methylation in neuroblastic tumors

  • Barbara Banelli

      Affiliations

    • Laboratory of Tumor Genetics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy
  • ,
  • Angela Di Vinci

      Affiliations

    • Laboratory of Tumor Genetics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy
  • ,
  • Ilaria Gelvi

      Affiliations

    • Laboratory of Tumor Genetics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy
  • ,
  • Ida Casciano

      Affiliations

    • Laboratory of Tumor Genetics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy
  • ,
  • Giorgio Allemanni

      Affiliations

    • Laboratory of Tumor Genetics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy
  • ,
  • Stefano Bonassi

      Affiliations

    • Laboratory of Environmental Epidemiology and Biostatistics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Genova, Italy
  • ,
  • Massimo Romani

      Affiliations

    • Laboratory of Tumor Genetics, Istituto Nazionale per la Ricerca sul Cancro—IST Genova, Largo Rosanna Benzi 10, 16132 Genova, Italy
    • Corresponding Author InformationCorresponding author. Tel./fax: +39 010 57 37 501.

Received 11 January 2005 ,Accepted 5 February 2005.

References 

  1. Tonini GP, Romani M. Genetic and epigenetic modifications in neuroblastoma. Cancer Lett. 2003;197:69–73
  2. Morgan HD, Dean W, Coker HA, Reik W, Petersen-Mahrt SK. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 2004;50:52353–52360
  3. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis. TIG. 1999;16:168–174
  4. Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol. 2003;4:351–358
  5. Laird PW. The power and promise of DNA methylation markers. Nat. Rev. Cancer. 2003;3:253–266
  6. Herman JG, Graff JR, Myohanen S, Nelkin B, Baylin SB. Methylation specific PCR: a novel PCR assay for methylation status of CpG island. Proc. Natl Acad. Sci. USA. 1996;93:9821–9826
  7. Esteller M, Herman JG. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumors. J. Pathol. 2002;196:1–7
  8. Szyf M, Pakneshan P, Rabbani SA. DNA demethylation cancer: therapeutic implications. Cancer Lett. 2004;211:133–143
  9. Kantarjian HM, O'Brien S, Cortes J, Giles FJ, Faderl S, Issa JP, et al. Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia. Cancer. 2003;98:522–528
  10. Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, et al. Association of multiple copies of the N-MYC oncogene with rapid progression of neuroblastomas. N. Engl. J. Med. 1985;313:1111–1116
  11. Oppenheimer O, Alaminos M, Gerald WL. Genomic medicine and neuroblastoma. Expert Rev. Mol. Diagn. 2003;3:39–54
  12. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc. Natl Acad. Sci. USA. 1999;96:8681–8686
  13. Alaminos M, Davalos V, Cheung NKV, Gerald WL, Esteller M. Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma. J. Natl Cancer Inst. 2004;96:1208–1219
  14. van Noesel MM, van Bezouw S, Salomons GS, Voute PA, Pieters R, Baylin SB, et al. Tumor-specific down regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation. Cancer Res. 2002;62:2157–2161
  15. B. Banelli, I. Gelvi, A. Di Vinci, P. Scaruffi, I. Casciano, G. Allemanni, et al., Distinct CpG methylation profiles characterize different clinical groups of neuroblastic tumors, Oncogene (2005) in press.
  16. Cheung B, Hocker JE, Smith SA, Norris MD, Haber M, Marshall GM. Favorable prognostic significance of high-level retinoic acid receptor beta expression in neuroblastoma mediated by effects on cell cycle regulation. Oncogene. 1998;17:751–775
  17. Wei T, Valentine MB, Vanin MF, Grenet J, Valentine VA, Behem BG, et al. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat. Med. 2000;6:529–535
  18. Banelli B, Casciano I, Croce M, Di Vinci A, Gelvi I, Pagnan G, et al. Expression and methylation of CASP8 in neuroblastoma: identification of a promoter region. Nat. Med. 2002;8:1333–1335
  19. Casciano I, De Ambrosis A, Croce M, Pagnan G, Di Vinci A, Allemanni G, et al. Expression of the caspase-8 gene in neuroblastoma cells is regulated through an essential interferon-sensitive response element (ISRE). Cell Death Differ. 2004;11:131–134
  20. Ferguson AT, Evron E, Umbricht CB, Chan TA, Hermeking H, Marks JR, et al. High frequency of hypermethylation at the 14.3.3σ locus leads to gene silencing in breast cancer. Proc. Natl Acad. Sci. USA. 2000;97:6049–6054
  21. Melino G, De Laurenzi V, Vousden KH. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer. 2002;2:605–615
  22. Casciano I, Mazzocco K, Boni L, Pagnan G, Banelli B, Allemanni G, et al. Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients. Cell Death Differ. 2002;9:246–251
  23. Casciano I, Banelli B, Croce M, Alemanni G, Ferrini S, Tonini GP, et al. Role of methylation in the control of ΔNp73 expression in neuroblastoma. Cell Death Differ. 2002;9:343–345
  24. Boily G, Saikali Z, Sinnett D. Methylation analysis of the glypican 3 gene in embryonal tumors. Br. J. Cancer. 2004;90:1606–1611
  25. Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukaemia. Blood. 1993;82:1820–1828

PII: S0304-3835(05)00356-3

doi: 10.1016/j.canlet.2005.02.049

Cancer Letters
Volume 228, Issue 1 , Pages 37-41 , 18 October 2005