Cancer Letters
Volume 234, Issue 2 , Pages 168-175 , 28 March 2006

Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice

Received 7 October 2004 ,Revised 11 March 2005 ,Accepted 22 March 2005.

References 

  1. National Institutes of Health Consensus Development Panel. Consensus statement: treatment of early-stage breast cancer. J. Natl Cancer Inst. Monogr. 1992;11:1–5
  2. Perez EA. Current management of metastatic breast cancer. Semin. Oncol. 1999;26(Suppl 12):1–10
  3. Chen JM, Stavro PM, Thompson LU. Dietary flaxseed inhibits breast cancer growth and metastasis and downregulates expression of epidermal growth factor receptor and insulin-like growth factor. Nutr. Cancer. 2002;43:187–192
  4. Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002;186:31–37
  5. Yan L, Yee JA, Li D, McGuire MH, Thompson LU. Dietary flaxseed supplementation and experimental metastasis of melanoma cells in mice. Cancer Lett. 1998;124:181–186
  6. Thompson LU, Robb P, Serraino M, Cheung F. Mammalian lignan production from various foods. Nutr. Cancer. 1991;16:43–52
  7. Bougnoux P, Chajes V. α-Linolenic acid and cancer. In:  Thompson LU,  Cunnane SC editor. Flaxseed in Human Nutrition. second ed.. Champaign, IL: AOCS Press; 2003;p. 232–244
  8. Thompson LU. Flaxseed, lignans, and cancer. In:  Thompson LU,  Cunnane SC editor. Flaxseed in Human Nutrition. second ed.. Champaign, IL: AOCS Press; 2003;p. 194–222
  9. Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett. 1991;60:135–142
  10. Serraino M, Thompson LU. The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutr. Cancer. 1992;17:153–159
  11. Thompson LU, Rickard SE, Orcheson LJ, Seidl M. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis. 1996;17:1373–1376
  12. Chen J, Hui E, Yip T, Thompson LU. Flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen receptor positive human breast cancer. Clin. Cancer Res. 2004;10:7703–7711
  13. Thompson LU, Seidl MM, Rickard SE, Orcheson LJ, Fong H. Antitumorigenic effect of a mammalian lignan precursor from flaxseed. Nutr. Cancer. 1996;26:159–165
  14. Prasad K. Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flaxseed. Mol. Cell. Biochem. 1997;168:117–123
  15. Yuan YV, Rickard SE, Thompson LU. Short term feeding of flaxseed or it lignan has minor influence on in vivo hepatic antioxidant status in young rats. Nutr. Res. 1999;19:1233–1243
  16. Fotsis T, Pepper M, Adlercreutz H, Fleischmann G, Hase T, Montesano R, et al. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl Acad. Sci. USA. 1993;90:2690–2694
  17. Retsky M, Bonadonna GR, Demicheli J, Folkman J, Hrushesky W, Valagussa P. Hypothesis: induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients. Breast Cancer Res. 2004;6:R372–R374
  18. Vinh-Hung V, Verschraegen C. Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. J. Natl Cancer Inst. 2004;96:115–121
  19. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 1993;123:1939–1951
  20. Chen J, Thompson LU. Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro. Breast Cancer Res. Treat. 2003;80:163–170
  21. Heinonen S, Nurmi T, Liukkonen K, Poutanen K, Wahala K, Deyama T, et al. In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. J. Agric. Food Chem. 2001;49:3178–3186
  22. Meagher LP, Beecher GR, Flanagan VP, Li BW. Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal. J. Agric. Food Chem. 1999;47:3173–3180
  23. Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett. 2000;161:47–55
  24. Price DJ, Miralem T, Jiang S, Steinberg R, Avraham H. Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell. Growth Differ. 2001;12:129–135
  25. Wu FP, Hoekman K, Meijer S, Cuesta MA. VEGF and endostatin levels in wound fluid and plasma after breast surgery. Angiogenesis. 2003;6:255–257
  26. Rose DP, Connolly JM. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol. Ther. 1999;83:217–244
  27. Rose DP, Connolly JM, Coleman M. Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice. Clin. Cancer Res. 1996;2:1751–1756
  28. Rose DP, Connolly JM. Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutr. Cancer. 2000;37:119–127
  29. Natarajan R, Nadler J. Role of lipoxygenases in breast cancer. Front. Biosci. 1998;8:E81–E88
  30. Rose DP, Connolly JM, Rayburn J, Coleman M. Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer in nude mice. J. Natl Cancer Inst. 1995;87:587–592
  31. Liu X-H, Connolly JM, Rose DP. Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line. Clin. Exp. Metastasis. 1996;14:145–152

PII: S0304-3835(05)00331-9

doi: 10.1016/j.canlet.2005.03.056

Cancer Letters
Volume 234, Issue 2 , Pages 168-175 , 28 March 2006