Cancer Letters
Volume 228, Issue 1 , Pages 71-81, 18 October 2005

High-resolution cDNA microarray-based comparative genomic hybridization analysis in neuroblastoma

  • Qing-Rong Chen

      Affiliations

    • Qing-Rong Chen and Sven Bilke: Equal contributor.
    • ,
  • Sven Bilke

      Affiliations

    • Qing-Rong Chen and Sven Bilke: Equal contributor.
    • ,
  • Javed Khan

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 301 435 2937; fax: +1 301 480 0314/402 3134.

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Government Circle, Gaithersburg, MD 20877, USA

Received 24 November 2004; accepted 14 December 2004.

Abstract 

Neuroblastoma (NB) is one of the most common pediatric solid tumors and displays a broad variety of genomic alterations. Array-based comparative genomic hybridization (A-CGH) is a novel technology enabling the high-resolution detection of DNA copy number aberrations. In this article, we outline features of this new technology and approaches of data analysis. We focus on stage specific DNA copy number variations in neuroblastoma detected by cDNA array-based comparative genomic hybridization (A-CGH). We also discuss hypothetic evolutionary models of neuroblastoma progression that can be derived from A-CGH data.

Keywords: Neuroblastoma, Array CGH, Microarray, Tumor evolution, DNA copy number, Genomic alteration, Amplification, MYCN

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PII: S0304-3835(05)00322-8

doi:10.1016/j.canlet.2004.12.056

Cancer Letters
Volume 228, Issue 1 , Pages 71-81, 18 October 2005

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