Cancer Letters
Volume 227, Issue 1 , Pages 49-57 , 8 September 2005

Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: A case–control analysis

  • Chunping Li

      Affiliations

    • Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • ,
  • Jia Liu

      Affiliations

    • Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • ,
  • Aiping Li

      Affiliations

    • Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • ,
  • Lixin Qian

      Affiliations

    • Department of Urological Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • ,
  • Xinru Wang

      Affiliations

    • Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • ,
  • Qingyi Wei

      Affiliations

    • Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Jianwei Zhou

      Affiliations

    • Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • Corresponding Author InformationCorresponding authors. Tel.: +86 25 8686 2961; fax: +86 25 8652 7613.
    • ,
  • Zhengdong Zhang

      Affiliations

    • Department of Molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, People's Republic of China
    • Corresponding Author InformationCorresponding authors. Tel.: +86 25 8686 2961; fax: +86 25 8652 7613.

Received 11 January 2005 ,Revised 25 March 2005 ,Accepted 28 March 2005.

References 

  1. Parkin DM. International variation. Oncogene. 2004;23:6329–6340
  2. Yang L, Parkin DM, Li LD, Chen YD, Bray F. Estimation and projection of the national profile of cancer mortality in China: 1991–2005. Br. J. Cancer. 2004;90:2157–2166
  3. Cohen SM, Shirai T, Steineck G. Epidemiology and etiology of premalignant and malignant urothelial changes. Scand. J. Urol. Nephrol. Suppl. 2000;205:105–115
  4. Benhamou S, Sarasin A. Variability in nucleotide excision repair and cancer risk: a review. Mutat. Res. 2000;462:149–158
  5. Pegg AE, Byers TL. Repair of DNA containing O6-alkylguanine. FASEB J. 1992;6:2302–2310
  6. Aquilina G, Biondo R, Dogliotti E, Meuth M, Bignami M. Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions. Cancer Res. 1992;52:6471–6475
  7. Pegg AE, Dolan ME, Moschel RC. Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. Prog. Nucleic Acid Res. Mol. Biol. 1995;51:167–223
  8. Skorpen F, Krokan HE. The methylation status of the gene for O6-methylguanine-DNA methyltransferase in human Mer+ and Mer− cells. Carcinogenesis. 1995;16:1857–1863
  9. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 1999;59:793–797
  10. Iwakuma T, Sakumi K, Nakatsuru Y, Kawate H, Igarashi H, Shiraishi A, et al. High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase. Carcinogenesis. 1997;18:1631–1635
  11. Rydberg B, Spurr N, Karran P. cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. J. Biol. Chem. 1990;265:9563–9569
  12. Natarajan AT, Vermeulen S, Darroudi F, Valentine MB, Brent TP, Mitra S, et al. Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization. Mutagenesis. 1992;7:83–85
  13. Otsuka M, Abe M, Nakabeppu Y, Sekiguchi M, Suzuki T. Polymorphism in the human O6-methylguanine-DNA methyltransferase gene detected by PCR-SSCP analysis. Pharmacogenetics. 1996;6:361–363
  14. Egyhazi S, Ma S, Smoczynski K, Hansson J, Platz A, Ringborg U. Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden. Hum. Mutat. 2002;20:408–409
  15. Deng C, Xie D, Capasso H, Zhao Y, Wang LD, Hong JY. Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region. Pharmacogenetics. 1999;9:81–87
  16. Liu R, Zhuang Z. Single-nucleotide polymorphisms of human O6-methylguanine-DNA methyltransferase (MGMT) gene in lung cancer patients from south China. J. Health Toxicol. 2002;16:1–5
  17. Liu R, Zhuang Z, He C, He Y. Relationship between genetic polymorphisms of human O6-methylguanine-DNA methyltransferase (MGMT) gene and susceptibility to tumors. Carcinog. Teratogen. Mutagen. 2002;14:101–106
  18. Ma S, Egyhazi S, Ueno T, Lindholm C, Kreklau EL, Stierner U, et al. O6-Methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma. Br. J. Cancer. 2003;89:1517–1523
  19. Krzesniak M, Butkiewicz D, Samojedny A, Chorazy M, Rusin M. Polymorphisms in TDG and MGMT genes-epidemiological and functional study in lung cancer patients from Poland. Ann. Hum. Genet. 2004;68:300–312
  20. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 2001;68:978–989
  21. Stephens M, Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 2003;73:1162–1169
  22. Badawi AF, Mostafa MH, O'Connor PJ. Involvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. Cancer Lett. 1992;63:171–188
  23. Hartge P, Harvey EB, Linehan WM, Silverman DT, Sullivan JW, Hoover RN, et al. Unexplained excess risk of bladder cancer in men. J. Natl. Cancer Inst. 1990;82:1636–1640
  24. Silverman DT, Hartge P, Morrison AS, Devesa SS. Epidemiology of bladder cancer. Hematol. Oncol. Clin. North Am. 1992;6:1–30
  25. Cohen SM, Johansson SL. Epidemiology and etiology of bladder cancer. Urol. Clin. North Am. 1992;19:421–428
  26. Riggs JE. Bladder cancer mortality in the United States, 1951–1989: increased environmental carcinogenesis in men. Regul. Toxicol. Pharmacol. 1994;20:187–197

PII: S0304-3835(05)00298-3

doi: 10.1016/j.canlet.2005.03.043

Cancer Letters
Volume 227, Issue 1 , Pages 49-57 , 8 September 2005

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