Cancer Letters
Volume 226, Issue 1 , Pages 49-54, 8 August 2005

A genetic polymorphism in prostaglandin synthase 2 (8473, T→C) and the risk of lung cancer

  • Mette Sørensen

      Affiliations

    • Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 35257626; fax: +45 35257731.
    • ,
  • Herman Autrup

      Affiliations

    • Department of Environmental and Occupational Medicine, University of Aarhus, DK-8000 Aarhus, Denmark
    • ,
  • Anne Tjønneland

      Affiliations

    • Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark
    • ,
  • Kim Overvad

      Affiliations

    • Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
    • ,
  • Ole Raaschou-Nielsen

      Affiliations

    • Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark

Received 31 January 2005; received in revised form 26 March 2005; accepted 28 March 2005.

Abstract 

Prostaglandin synthase 2 (PTGS2) mediated production of prostaglandins is an important step in the inflammatory response. In a population-based case-cohort study, we investigated the relationship between lung cancer and a polymorphism in PTGS2 at site 8473. Among 54,220 cohort members, 265 lung cancer cases and a comparison group of 272 individuals were identified. We found no overall significant association between the PTGS2 polymorphism and lung cancer risk, though the results indicated a lower risk in subjects carrying one copy (RR 0.87; 95% CI 0.61–1.25) or two copies (RR 0.58; 95% CI 0.30–1.12) of the variant allele compared with subjects carrying two copies of the wildtype allele. This tendency seemed to be strongest among the youngest subjects (50–55 years) with a RR on 0.48 (0.19–1.22) in carriers of one variant allele and 0.21 (0.04–1.07) in carriers of two variant alleles, and a significant trend (P=0.04). These results indicate that PTGS2 could be implicated in the development of lung cancer.

Keywords: PTGS2, Polymorphism, Lung neoplasm, Case-cohort study, Epidemiology

Abbreviations: PTGS2, prostaglandin synthase 2, RR, rate ratio, CI, confidence interval

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PII: S0304-3835(05)00289-2

doi:10.1016/j.canlet.2005.03.037

Cancer Letters
Volume 226, Issue 1 , Pages 49-54, 8 August 2005

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