Cancer Letters
Volume 234, Issue 2 , Pages 149-157 , 28 March 2006

Conjugated linoleic acid induces apoptosis in MDA-MB-231 breast cancer cells through ERK/MAPK signalling and mitochondrial pathway

Received 31 January 2005 ,Revised 18 March 2005 ,Accepted 20 March 2005.

References 

  1. Hopkins GJ, Kennedy TG, Carroll KK. Polyunsaturated fatty acids as promoters of mammary carcinogenesis induced in Sprague–Dawley rats by 7,12-dimethylbenz(a) anthracene. J. Natl. Cancer Inst. 1981;66:517–522
  2. Escrich E, Solanas M, Soler M, Ruiz de Villa MC, Sanchez JA, Segura R. Dietary polyunsaturated n-6 lipids effects on the growth and fatty acid composition of rat mammary tumors. J. Nutr. Biochem. 2001;12:536–549
  3. Stripp C, Overvad K, Christensen J, Thomsen BL, Olsen A, Moller S, et al. Fish intake is positively associated with breast cancer incidence rate. J. Nutr. 2003;133:3664–3669
  4. Stoll BA. N-3 fatty acids and lipid peroxidation in breast cancer inhibition. Br. J. Nutr. 2002;87:193–198
  5. Ip C, Dong Y, Ip MM, Banni S, Carta G, Angioni E, et al. Conjugated linoleic acid isomers and mammary cancer prevention. Nutr. Cancer. 2002;43:52–58
  6. Ip C, Carter CA, Ip MM. Requirement of essential fatty acid for mammary tumorigenesis in the rat. Cancer Res. 1985;45:1997–2001
  7. Belury MA, Nickel KP, Bird CE, Wu Y. Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. Nutr. Cancer. 1996;26:149–157
  8. Shultz TD, Chew BP, Seaman WR. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res. 1992;12:2143–2145
  9. Park Y, Allen KG, Shultz TD. Modulation of MCF-7 breast cancer cell signal transduction by linoleic acid and conjugated linoleic acid in culture. Anticancer Res. 2000;20:669–676
  10. Maggiora M, Bologna M, Ceru MP, Possati L, Angelucci A, Cimini A, et al. An overview of the effect of linoleic and conjugated-linoleic acids on the growth of several human tumor cell lines. Int. J. Cancer. 2004;112:909–919
  11. Song HJ, Sneddon AA, Barker PA, Bestwick C, Choe SN, McClinton S, et al. Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells. Nutr. Cancer. 2004;49:100–108
  12. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298:1911–1912
  13. Nagata Y, Todokoro K. Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. Blood. 1999;94:853–863
  14. Koo HM, VanBrocklin M, McWilliams MJ, Leppla SH, Duesbery NS, Woude GF. Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. Proc. Natl Acad. Sci USA. 2002;99:3052–3057
  15. Jan MS, Liu HS, Lin YS. Bad overexpression sensitizes NIH/3T3 cells to undergo apoptosis which involves caspase activation and ERK inactivation. Biochem. Biophys. Res. Commun. 1999;264:724–729
  16. Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 2000;10:369–377
  17. Jiang X, Wang X. Cytochrome C-mediated apoptosis. Annu. Rev. Biochem. 2004;73:87–106
  18. Huang Z. Bcl-2 family proteins as targets for anticancer drug design. Oncogene. 2000;19:6627–6631
  19. Hartree EF. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal. Biochem. 1972;48:422–427
  20. Kim EJ, Kang IJ, Cho HJ, Kim WK, Ha YL, Park JH. Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. J. Nutr. 2003;133:2675–2681
  21. Masso-Welch PA, Zangani D, Ip C, Vaughan MM, Shoemaker SF, McGee SO, et al. Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature. J. Nutr. 2004;134:299–307
  22. Oh YS, Lee HS, Cho HJ, Lee SG, Jung KC, Park JH. Conjugated linoleic acid inhibits DNA synthesis and induces apoptosis in TSU-Pr1 human bladder cancer cells. Anticancer Res. 2003;23:4765–4772
  23. Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KW. Conjugated linoleic acids (CLA's) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis. 2004;25:1185–1191
  24. Chujo H, Yamasaki M, Nou S, Koyanagi N, Tachibana H, Yamada K. Effect of conjugated linoleic acid isomers on growth factor-induced proliferation of human breast cancer cells. Cancer Lett. 2003;202:81–87
  25. Tanmahasamut P, Liu J, Hendry LB, Sidell N. Conjugated linoleic Acid blocks estrogen signaling in human breast cancer cells. J. Nutr. 2004;134:674–680
  26. Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. Int. J. Oncol. 2004;24:591–608
  27. Majumder B, Wahle KW, Moir S, Schofield A, Choe SN, Farquharson A, et al. Conjugated linoleic acids (CLAs) regulate the expression of key apoptotic genes in human breast cancer cells. Fed. Am. Soc. Exp. Biol. J. 2002;16:1447–1449
  28. Wang GQ, Gastman BR, Wieckowski E, Goldstein LA, Gambotto A, Kim TH, et al. A role for mitochondrial Bak in apoptotic response to anticancer drugs. J. Biol. Chem. 2001;276:34307–34317
  29. Loeffler M, Kroemer G. The mitochondrion in cell death control: certainties and incognita. Exp. Cell Res. 2000;256:19–26
  30. Griffiths GJ, Dubrez L, Morgan CP, Jones N, Whitehouse J, Corfe BM, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J. Cell Biol. 1999;144:903–914
  31. Holinger EP, Chittenden T, Lutz RJ. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J. Biol. Chem. 1999;274:13298–13304
  32. Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, et al. Identification of chelerythrine as an inhibitor of BclXL function. J. Biol. Chem. 2003;278:20453–20456
  33. Small GW, Somasundaram S, Moore DT, Shi YY, Orlowski RZ. Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK. J. Pharmacol. Exp. Ther. 2003;307:861–869
  34. Gulbins E, Dreschers S, Bock J. Role of mitochondria in apoptosis. Exp. Physiol. 2003;88:85–90
  35. Durgam VR, Fernandes G. The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. Cancer Lett. 1997;116:121–130

PII: S0304-3835(05)00280-6

doi: 10.1016/j.canlet.2005.03.029

Cancer Letters
Volume 234, Issue 2 , Pages 149-157 , 28 March 2006

Article Tools

* Image Usage & Resolution