Cancer Letters
Volume 225, Issue 1 , Pages 99-103 , 8 July 2005

Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer

Received 5 January 2005 ,Revised 5 February 2005 ,Accepted 6 February 2005.

References 

  1. Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sci. 2004;75:639–653
  2. Jaiswal M, LaRusso NF, Gores GJ. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 2001;281:G626–G634
  3. Thomsen LL, Miles DW, Happerfield L, Bobrow LG, Knowles RG, Moncada S. Nitric oxide synthase activity in human breast cancer. Br. J. Cancer. 1995;72:41–44
  4. Cobbs CS, Brenman JE, Aldape KD, Bredt DS, Israel MA. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res. 1995;55:727–730
  5. Fransén K, Dimberg J, Österström A, Olsson A, Söderkvist P, Sirsjö A. Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas. Surgery. 2002;131:384–392
  6. Xu W, Liu L, Emson PC, Harrington CR, Charles IG. Evolution of a homopurine–homopyrimidine pentanucleotide repeat sequence upstream of the human inducible nitric oxide synthase gene. Gene. 1997;204:165–170
  7. Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K. Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand. J. Infect. Dis. 2002;186:578–581
  8. Konno S, Hizawa N, Yamaguchi E, Jinushi E, Nishimura M. (CCTTT)n repeat polymorphism in the NOS2 gene promoter is associated with atopy. J. Allergy Clin. Immunol. 2001;108:810–814
  9. Warphea KM, Xu W, Liu L, Charles G, Patterson CC, Ah-Fat F, et al. Genotyping and functional analysis of a polymorphic (CCTTT)n repeat of NOS2A in diabetic retinopathy. Fed. Am. Soc. Exp. Biol. 1999;13:1825–1832
  10. Morris BJ, Markus MA, Glenn CL, Adams DJ, Colagiuri S, Wang XL. Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. J. Mol. Med. 2002;80:96–104
  11. Hobbs MR, Udhayakumar V, Levesque MC, Booth J, Roberts JM, Tkachuk AN, et al. A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. Lancet. 2002;360:1468–1475
  12. Kun J, Mordmuller B. Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet. 1998;351:265–266
  13. Fransén K, Klintenäs M, Österström A, Dimberg J, Monstein H-J, Söderkvist P. Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. Carcinogenesis. 2004;25:527–533
  14. Johannesen J, Pociot F, Kristiansen OP, Karlsen AE, Nerup J. DIEGG, DSGD, no evidence for linkage in the promoter region of the inducible nitric oxide synthase gene (NOS2) in a Danish type 1 diabetes population. Genes Immun. 2000;1:362–366
  15. Gonzalez-Gay MA, Llorca J, Sanchez E, Lopez-Nevot MA, Amoli MM, Garcia-Porrua C, et al. Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain. Rheumatology. 2004;43:1182–1185
  16. Levesque MC, Hobbs MR, Anstey NM, Vaughn TN, Chancellor JA, Pole A, et al. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J. Infect. Dis. 1999;180:1994–2002
  17. Pascual M, López-Nevot MA, Cáliz R, Koeleman BPC, Balsa A, Pasqual-Salcedo D, et al. Genetic determinants of rheumatoid arthritis: the inducible nitric oxide synthase (NOS2) gene promoter polymorphism. Genes Immun. 2002;3:299–301
  18. Boutlis CS, Hobbs MR, Marsh RL, Misukonis MA, Tkachuk AN, Lagog M, et al. Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. Am. J. Trop. Med. Hyg. 2003;69:569–573

PII: S0304-3835(05)00128-X

doi: 10.1016/j.canlet.2005.02.006

Cancer Letters
Volume 225, Issue 1 , Pages 99-103 , 8 July 2005

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