Cancer Letters
Volume 229, Issue 1 , Pages 67-75 , 8 November 2005

In vitro toxicity evaluation in the development of new anticancer drugs—genistein glycosides

Received 23 December 2004 ,Revised 31 December 2004 ,Accepted 17 January 2005.

References 

  1. Pessina A, Albella B, Bueren J, Brantom P, Casati S, Gribaldo L, et al. Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay. Toxicol In Vitro. 2001;15:729–740
  2. Pessina A, Albella B, Bayo M, Bueren J, Brantom P, Casati S, et al. Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. Toxicol Sci. 2003;75:355–367
  3. Spielmann H, Genschow M, Liebsch M, Halle W. Determination of the starting dose for acute oral toxicity (LD50) testing in the up and down procedure (UDP) from cytotoxicity data. Altern. Lab. Anim. 1999;27:957–966
  4. OECD (Organisation for Economic Co-operation and Development), OECD Guideline for Testing of Chemicals, 423, Acute Oral Toxicity—Acute Toxic Class Method, OECD, Paris, 1996, Updated in 2000: http://www.oecd.org/ehs/test/testlist.htm.
  5. OECD (Organisation for Economic Co-operation and Development), OECD Guideline for Testing of Chemicals, 425, Acute Oral Toxicity—Up-and-Down Procedure, OECD, Paris, 1998, Updated in 2000: http://www.oecd.org/ehs/test/testlist.htm.
  6. National Institute of Environmental Health Sciences (NIEHS), Guidance Document on using in vitro Data to Estimate in vivo Staring Doses for Acute Toxicity, NIH Publication 01-4500, NIEHS, Research Triangle Park, NC, 2001.
  7. Rogiers V. Ecopa: actual status and plans. Toxicol In Vitro. 2003;17:779–784
  8. Aaronson SA, Todaro GJ. Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40. J. Cell. Physiol. 1968;72:141–148
  9. Polkowski K, Popiolkiewicz J, Krzeczynski P, Ramza J, Pucko W, Zegrocka-Stendel O, et al. Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines. Cancer Lett. 2004;203:59–69
  10. Polkowski K, Mazurek AP. Biological properties of genistein—a review of in vitro and in vivo data. Acta Pol. Pharm. 2000;57:135–155
  11. Markovits J, Linassier C, Fosse P, Couprie J, Pierre J, Jacquemin-Sablon A, et al. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res. 1989;49:5111–5117
  12. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe SI, Itoh N, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 1987;262:5592–5595
  13. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GI, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J. Nutr. 1999;129:1628–1635
  14. Cai Q, Wei H. Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutr. Cancer. 1996;25:1–7
  15. Kyle E, Neckers L, Takimoto C, Curt G, Bergan R. Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol. Pharmacol. 1997;51:193–200
  16. Constantinou AI, Krygier AE, Mehta RR. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. Am. J. Clin. Nutr. 1998;68:1426S–1430S
  17. Lian F, Li Y, Bhuiyan M, Sarkar FH. p53-Independent apoptosis induced by genistein in lung cancer cells. Nutr. Cancer. 1998;33:125–131
  18. Okazaki K, Okazaki S, Nakamura H, Kitamura Y, Hatayama H, Wakabayashi S, et al. A repeated 28-day oral dose toxicity study of genistein in rats, based on the Enhanced OECD Test Guideline 407; for screening endocrine-disrupting chemicals. Arch. Toxicol. 2002;76:553–559
  19. Boryski J, Grynkiewicz G. A regioselective synthesis of genistein 4′–O–ribofuranosides. Synthesis. 2001;14:2170–2174
  20. Borenfreund E, Puerner JA. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 1985;24:119–124
  21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immun. Meth. 1983;65:55–63
  22. National Institute of Environmental Health Sciences (NIEHS), Report of the International Workshop on in vitro Methods for Assessing, Acute Systemic Toxicity, NIH Publication 01-4499, NIEHS, Research Triangle Park, NC, 2001.
  23. Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl Cancer Inst. 1991;83:757–766

PII: S0304-3835(05)00069-8

doi: 10.1016/j.canlet.2005.01.014

Cancer Letters
Volume 229, Issue 1 , Pages 67-75 , 8 November 2005

Article Tools

* Image Usage & Resolution