Cancer Letters
Volume 230, Issue 2 , Pages 284-291 , 18 December 2005

Cytogenetic effects in children treated with methylphenidate

  • Randa A. El-Zein

      Affiliations

    • Department of Epidemiology, Box 189, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Sherif Z. Abdel-Rahman

      Affiliations

    • Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2.102 Ewing Hall, Galveston, TX 77555-1110, USA
    • ,
  • Matthew J. Hay

      Affiliations

    • Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2.102 Ewing Hall, Galveston, TX 77555-1110, USA
    • ,
  • Mirtha S. Lopez

      Affiliations

    • Department of Epidemiology, Box 189, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Melissa L. Bondy

      Affiliations

    • Department of Epidemiology, Box 189, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Debra L. Morris

      Affiliations

    • Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2.102 Ewing Hall, Galveston, TX 77555-1110, USA
    • ,
  • Marvin S. Legator

      Affiliations

    • Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2.102 Ewing Hall, Galveston, TX 77555-1110, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 409 772 1803; fax: +1 409 772 9108.

Received 22 November 2004 ,Revised 6 January 2005 ,Accepted 10 January 2005.

References 

  1. Swanson JM, Lerner M, Williams L. More frequent diagnosis of attention deficit-hyperactivity disorder. N. Engl. J. Med. 1995;333:944
  2. T. Woodworth, DEA Congressional Testimony, http://www.dea.gov/pubs/cngrtest/ct051600.htm.
  3. Dunnick JK, Hailey JR. Experimental studies on the long-term effects of methylphenidate hydrochloride. Toxicology. 1995;103:77–84
  4. Dunnick JK, Elwell MR, Haseman JK. Decreased incidence of spontaneous mammary gland neoplasms in female F344 rats treated with amphetamine, methylphenidate, or codeine. Cancer Lett. 1996;102:77–83
  5. Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ. Mutagen. 1986;7:1–119
  6. NTP, National Toxicology Program Carcinogenesis technical report series; National Toxicology Program; US Department of Health and Human Services 439 (1995) 1–70.
  7. Teo SK, San RH, Wagner VO, Gudi R, Stirling DI, Thomas SD, et al. D-Methylphenidate is non-genotoxic in in vitro and in vivo assays. Mutat. Res. 2003;537:67–79
  8. Rudd CJ, Mitchell AD, Spalding J. Mouse lymphoma cell mutagenesis assay of coded chemicals incorporating analyses of the colony size distributions. Environ. Mol. Mutagen. 1983;5:419
  9. Price PJ, Gregory EA, Skeen PC. Ritalin, benzedrine and dexedrine do not transform F 1706 rat cells. Cancer Lett. 1978;5:345–349
  10. Matthews EJ, Spalding JW, Tennant RW. Transformation of BALB/c-3T3 cells: V. Transformation responses of 168 chemicals compared with mutagenicity in Salmonella and carcinogenicity in rodent bioassays. Environ. Health Perspect. 1993;101:347–482
  11. Gallaway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, et al. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells, evaluation of 108 chemicals. Environ. Mol. Mutagen. 1987;10:1–175
  12. Walker AP, Dumars KW. Commonly used pediatric drugs, sister chromatid exchanges and the cell cycle. Am. J. Hum. Genet. 1977;29:110A
  13. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR (2000).
  14. Hsu TC, Johnston DA, Cherry LM, Ramkisson D, Schantz SP, Jessup JM, et al. Sensitivity to genotoxic effects of bleomycin in humans: possible relationship to environmental carcinogenesis. Int. J. Cancer. 1989;43:403–409
  15. Perry P, Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature. 1974;251:156–158
  16. Fenech M. Biomarkers of genetic damage for cancer epidemiology. Toxicology. 2002;181:411–416
  17. Fenech, M. The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ. Health Perspect. 1993;101:101–107
  18. Ellenhorn MJ, Barceloux DG. Medical Toxicology- Diagnosis and Treatment of Human Poisoning. In: New York, NY: Elsevier Science Publishing Co., Inc.; 1988;p. 631
  19. Bonassi S, Znaor A, Norppa H, Hagmar L. Chromosomal aberrations and risk of cancer in humans: an epidemiological perspective. Cytogenet. Genome Res. 2004;104:376–382
  20. Selby JV, Friedman GD, Fireman BH. Screening prescription drugs for possible carcinogenicity:eleven to fifteen years of follow-up. Cancer Res. 1989;49:5736–5747
  21. Li JH, Hu HC, Chen WB, Lin SK. Genetic toxicity of methamphetamine in vitro and in human abusers. Environ. Mol. Mutagen. 2003;42:233–242
  22. Abdel-Rahman SZ, El-Zein RA. The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK. Cancer Lett. 2000;159:63–71
  23. Abdel-Rahman SZ, Ammenheuser MM, Ward JB. Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms. Carcinogenesis. 2001;22:415–423
  24. Affatato A, Wolfe KJ, Lopez MS, Hallberg C, Ammenheuser MM, Abdel-Rahman SZ. Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. Environ. Mol. Mutagen. 2004;44:65–73

PII: S0304-3835(05)00037-6

doi: 10.1016/j.canlet.2005.01.003

Cancer Letters
Volume 230, Issue 2 , Pages 284-291 , 18 December 2005

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