Cancer Letters
Volume 230, Issue 1 , Pages 65-71 , 8 December 2005

A novel loss-of-function deletion in sodium/iodide symporter gene in follicular thyroid adenoma

  • Ji-An Liang

      Affiliations

    • Departments of Radiation Therapy and Oncology, China Medical University Hospital, Taichung, Taiwan, ROC
    • ,
  • Chun-Ping Chen

      Affiliations

    • Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC
    • ,
  • Shin-Jer Huang

      Affiliations

    • Department of Surgery, China Medical University Hospital, Taichung, Taiwan, ROC
    • ,
  • Tin-Yun Ho

      Affiliations

    • Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, ROC
    • ,
  • Chien-Yun Hsiang

      Affiliations

    • Departments of Microbiology, China Medical University, Taichung, Taiwan, ROC
    • ,
  • Hueisch-Jy Ding

      Affiliations

    • Department of Radiological Technology, I-Shou University, Kaohsiung, Taiwan, ROC
    • ,
  • Shih-Lu Wu

      Affiliations

    • Department of Biochemistry, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan, ROC
    • Corresponding Author InformationCorresponding author. Tel.: +886 4 2205 3366x8610; fax: +886 4 2205 3764.

Received 20 September 2004 ,Revised 15 December 2004 ,Accepted 18 December 2004.

References 

  1. De La Vieja A, Dohan O, Levy O, Carrasco N. Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Physiol. Rev. 2000;80:1083–1105
  2. Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, et al. The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocrinol. Rev. 2003;24:48–77
  3. Mazaferri EL. Carcinoma of the follicular epithelium. In:  Braverman LE,  Utiger R editor. The Thyroid: A Fundamental and Clinical Text. eighth ed.. Philadephia: Lippincott; 2000;p. 904–930
  4. Piotr C, Nicoletta S. Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Anal. Biochem. 1987;162:156–159
  5. Matsuda A, Kosugi S. A homozygous missense mutation of the sodium/iodide symporter gene causing iodide transport defect. J. Clin. Endocrinol. Metab. 1997;82:3966–3971
  6. Kosugi S, Sato Y, Matsuda A, Ohyama Y, Fujieda K, Inomata H, et al. High prevalence of T354P sodium/iodide symporter gene mutation in Japanese patients with iodide transport defect who have heterogeneous clinical pictures. J. Clin. Endocrinol. Metab. 1998;83:4123–4129
  7. Fujiwara H, Tatsumi K, Miki K, Harada T, Okada S, Nose O, et al. Recurrent T354P mutation of the Na+/I-symporter in patients with iodide transport defect. J. Clin. Endocrinol. Metab. 1998;83:2940–2943
  8. Kosugi S, Bhyayana S, Dean HJ. A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. J. Clin. Endocrinol. Metab. 1999;84:3248–3253
  9. Fujiwara H, Tatsumi K, Tanaka S, Kimura M, Nose O, Amino N. A novel V59E missense mutation in the sodium iodide symporter gene in a family with iodide transport defect. Thyroid. 2000;10:471–474
  10. Pohlenz J, Medeiros-Neto G, Gross JL, Silveiro SP, Knobel M, Refetoff S. Hypothyroidism in a Brazilian kindred due to iodide trapping defect caused by a homozygous mutation in the sodium/iodide symporter gene. Biochem. Biophys. Res. Commun. 1997;240:488–491
  11. Pohlenz J, Rosenthal IM, Weiss RE, Jhiang SM, Burant C, Refetoff S. Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3′ splice site. J. Clin. Invest. 1998;101:1028–1035
  12. Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996;279:458–460
  13. Spitzweg C, Harrington KJ, Pinke LA, Vile RG, Morris JC. Clinical review 132: the sodium iodide symporter and its potential role in cancer therapy. J. Clin. Endocrinol. Metab. 2001;86:3327–3335

PII: S0304-3835(04)01002-X

doi: 10.1016/j.canlet.2004.12.036

Cancer Letters
Volume 230, Issue 1 , Pages 65-71 , 8 December 2005

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