Cancer Letters
Volume 230, Issue 1 , Pages 90-101 , 8 December 2005

Diphenylmethyl selenocyanate inhibits DMBA–croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation

Received 28 October 2004 ,Revised 15 December 2004 ,Accepted 18 December 2004.

References 

  1. Clark LC, Combs GF, Turnbull BW, Slate EH, Chalker DK, Chow MD, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional prevention of cancer study group. J. Am. Med. Assoc. 1996;276:1957–1963
  2. Yu SY, Zhu YJ, Li WG. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol. Trace Elem. Res. 1997;56:117–124
  3. Ip C. Lessons from basic research in selenium and cancer prevention. J. Nutr. 1998;128:1845–1854
  4. Abdullaev FI, Frenkel GD. Time-course of inhibition of cellular nucleic acid synthesis by selenite. J. Inorg. Biochem. 1994;55:113–121
  5. Lu J, Jiang C, Kaeck M, Ganther H, Vadhanavikit S, Ip C, et al. Dissociation of the genotoxic and growth inhibitory effects of selenium. Biochem. Pharmacol. 1995;50:213–219
  6. Lu J, Pei H, Ip C, Lisk DJ, Ganther H, Thompson HJ. Effect of an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention. Carcinogenesis. 1996;17:1903–1907
  7. Sinha R, Said TK, Medina D. Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways. Cancer Lett. 1996;107:277–284
  8. Kaeck M, Lu J, Strange R, Ip C, Ganther HE, Thompson HJ. Differential induction of growth arrest inducible genes by selenium compounds. Biochem. Pharmacol. 1997;53:921–926
  9. Sinha R, Medina D. Inhibition of cdk2 kinase activity by methylselenocysteine in synchronized mouse mammary epithelial tumor cells. Carcinogenesis. 1997;18:1541–1547
  10. Redman C, Scott JA, Baines AT, Basye JL, Clark LC, Calley C, et al. Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Lett. 1998;125:103–110
  11. Thompson HJ, Wilson A, Lu J, Singh M, Jiang C, Upadhyaya P, et al. Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line. Carcinogenesis. 1994;15:183–186
  12. Ronai Z, Tillotson JK, Traganos F, Darzynkiewicz Z, Conaway CC, Upadhyaya P, et al. Effects of organic and inorganic selenium compounds on rat mammary tumor cells. Int. J. Cancer. 1995;63:428–434
  13. Lu J, Jiang C, Kaeck M, Ganther H, Ip C, Thompson H. Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model. Carcinogenesis. 1995;16:513–517
  14. Ip C, Thomson HJ, Ganther HE. Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland. Cancer Epidemiol. Biomarkers Prev. 2000;9:49–54
  15. Ip C, Lisk DJ, Thompson HJ. Selenium-enriched garlic inhibits the early stage but not the late stage of mammary carcinogenesis. Carcinogenesis. 1996;17:1979–1982
  16. Stewart MJ, Davis RL, Walsh LP, Pence BC. Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29). Cancer Lett. 1997;117:35–40
  17. Kim T, Jung U, Cho DY, Chung AS. Se-Methylselenocysteine induces apoptosis through caspase activation in HL-60 cells. Carcinogenesis. 2001;22:559–565
  18. Park HS, Huh SH, Kim Y, Shim J, Lee SH, Park S, et al. Selenite negatively regulates caspase-3 through a redox mechanism. J. Biol. Chem. 2000;275:8487–8491
  19. Das RK, Ghosh S, Sengupta A, Das S, Bhattacharya S. Inhibition of DMBA/croton oil-induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate. Eur. J. Cancer Prev. 2004;13:411–417
  20. Das RK, Bhattacharya S. Inhibition of DMBA–croton oil two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate through modulation of cutaneous oxidative stress and inhibition of nitric oxide production. Asian Pacific J. Cancer Prev. 2004;5:151–158
  21. Pedersen CTh. Preparation of some 4-substituted selenosemicarbazides. Acta Chem. Scand. 1963;17:1459–1461
  22. Davidson LA, Brown RE, Chang WL, Morris JS, Wang N, Carroll RJ, et al. Morphodensitometric analysis of protein kinase C βII expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis. Carcinogenesis. 2000;21:1513–1519
  23. Caderni C, DeFilippo C, Luceri C, Salvadori M, Giannini A, Biggeri A, et al. Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats. Carcinogenesis. 2000;21:1965–1969
  24. Jaeschke H, Fisher MA, Lawson JA, Simmons CA, Fahood A, Jones D. Activation of caspase-3 (CPP32)-like protease is essential for TNF-α induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J. Immunol. 1998;160:3480–3486
  25. Kim HS, Hausman DB, Comton MM, Dean RG, Martin RJ, Hausman GJ, et al. Induction of apoptosis by All-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. Biochem. Biophys. Res. Commun. 2000;270:76–80
  26. Kunstle G, Hentze H, Germann PG, Tiegs G, Meergans T, Wendel A. Concanavalin A hepatotoxicity in mice. Tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation. Hepatology. 1999;30:1241–1251
  27. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folinphenol reagent. J. Biol. Chem. 1951;193:265–276
  28. Milner JA, Pigott MA, Dipple A. Selective effects of sodium selenite on 7,12-dimethylbenz[a]anthracene DNA binding in fetal mouse cell cultures. Cancer Res. 1985;45:6347–6354
  29. Zhu S, Gray TE, Nettesheim P. The effect of sodium selenite on cell proliferation and transformation of primary rat tracheal epithelial cells. Carcinogenesis. 1992;13:1725–1729
  30. Gopalakrishna R, Chen ZH, Gundimeda U. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch. Biochem. Biophys. 1997;348:37–48
  31. Gong Y, Frenkel GD. Effect of selenite on tumor cell invasiveness. Cancer Lett. 1994;78:195–199
  32. Yan L, Yee JA, Li D, McGuire MH, Graef GL. Dietary supplementation of selenomethionine reduces metastasis of melanoma cells in mice. Anticancer Res. 1999;19:1337–1342
  33. Jiang C, Jiang W, Ip C, Ganther H, Lu J. Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake. Mol. Carcinog. 1999;26:213–225
  34. S. Ghosh, R.K. Das, A. Sengupta, S. Bhattacharya, Induction of apoptosis and inhibition of cell proliferation by diphenylmethyl selenocyanate during azoxymethane induced rat colon carcinogenesis, Int. J. Cancer Prev. 3 (2005), in press.
  35. Jiang C, Wang Z, Ganther H, Lu J. Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU-145 human prostate cancer cells. Mol. Cancer Ther. 2002;1059–1066
  36. Jiang C, Wang Z, Ganther H, Lu J. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res. 2001;61:3062–3070
  37. Medina D, Oborn CJ. Selenium inhibition of DNA synthesis in mouse mammary epithelial cell line YN-4. Cancer Res. 1984;44:4361–4365
  38. Fico ME, Poirier KA, Watrach AM, Milner JA. Differential effects of selenium on normal and neoplastic canine mammary cells. Cancer Res. 1986;46:3384–3388
  39. Medina D, Oborn CJ. Differential effects of selenium on the growth of mouse mammary cells in vitro. Cancer Lett. 1981;13:333–344
  40. Frenkel GD, Flavey D. Evidence for the involvement of sylfhydryl compounds in the inhibition of cellular DNA synthesis by selenite. Mol. Pharmacol. 1988;34:573–577
  41. Sinha R, Kiley SC, Lu JX, Thompson JJ, Moraes R. Effects of methylsenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells. Cancer Lett. 1999;146:135–145
  42. O'Brein TG, Megosh LC, Gilliard G, Soler AP. Ornithine decarboxylase over expression is a sufficient condition for tumor promotion in mouse skin. Cancer Res. 1997;57:2630–2637
  43. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. Fed. Am. Soc. Exp. Biol. J. 1996;10:587–597
  44. Nicholson DW, Thomberry NA. Caspases: killer proteases. Trends Biochem. Sci. 1997;22:299–306

PII: S0304-3835(04)00999-1

doi: 10.1016/j.canlet.2004.12.021

Cancer Letters
Volume 230, Issue 1 , Pages 90-101 , 8 December 2005

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