Cyclin D1 G870A polymorphism and squamous cell carcinoma of the uterine cervix in Korean women

Jeon, Yong-Tark; Kim, Jae Weon; Song, Jung Han; Park, Noh-Hyun; Song, Yong-Sang; Kang, Soon-Beom; Lee, Hyo-Pyo

doi:10.1016/j.canlet.2004.12.024

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Volume 223, Issue 2 , Pages 259-263, 8 June 2005

Cyclin D1 G870A polymorphism and squamous cell carcinoma of the uterine cervix in Korean women

Yong-Tark Jeon
- Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, 110-744 Seoul, South Korea
- Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
Jae Weon Kim
- Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, 110-744 Seoul, South Korea
- Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
- Human Genome Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
- Corresponding author. Tel.: +82 2 2072 3511; fax: +82 2 762 3599.
Jung Han Song
- Department of Laboratory Medicine, College of Medicine, Seoul National University, Seoul, South Korea
Noh-Hyun Park
- Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, 110-744 Seoul, South Korea
- Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
Yong-Sang Song
- Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, 110-744 Seoul, South Korea
- Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
Soon-Beom Kang
- Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, 110-744 Seoul, South Korea
- Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea
Hyo-Pyo Lee
- Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Jongno-Gu, 110-744 Seoul, South Korea
- Cancer Research Institute, College of Medicine, Seoul National University, Seoul, South Korea

Received 24 October 2004; received in revised form 15 December 2004; accepted 18 December 2004.

Abstract

Though many investigators have reported relationships between the CCND1 polymorphism and susceptibility to various carcinomas, to our knowledge, no report has been issued concerning its relationship with uterine cervical cancer. Thus, we undertook this study to investigate the association between CCND1 polymorphisms and susceptibility to cervical cancer in Korean women. This study was carried on 222 patients with squamous cell carcinoma of uterine cervix and on 314 normal controls. CCND1 genotyping was determined by polymerase chain reaction and restriction fragment length polymorphism. The allelic frequencies of the cases (A, 0.53; G, 0.47) were not significantly different from those of the controls (A, 0.49; G, 0.51) (P=0.238). Regression analysis after adjusting for age showed that the CCND1 G870A genotypes are not related to the risk of squamous cell carcinoma of the uterine cervix. Our findings suggest that the CCND1 polymorphism is not associated with an increased risk of squamous cell carcinoma of uterine cervix in Korean women.

Keywords: Cervical cancer, Cyclin D1, Polymorphism