Cancer Letters
Volume 230, Issue 1 , Pages 20-24 , 8 December 2005

Association of human herpesvirus type 6 DNA with human bladder cancer

  • Alberto L. Escudero

      Affiliations

    • Biomedical Research Unit, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain
    • ,
  • Rafael J. Luque

      Affiliations

    • Department of Pathology, Faculty of Medicine, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain
    • ,
  • Ana Quintero

      Affiliations

    • Biomedical Research Unit, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain
    • ,
  • Jose Alvarez-Kindelan

      Affiliations

    • Urology Service, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain
    • ,
  • Maria J. Requena

      Affiliations

    • Urology Service, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain
    • ,
  • Rodolfo Montironi

      Affiliations

    • Department of Pathology, Marche Region University, Via Conca, 60020 Torrete di Ancona, Italy
    • ,
  • Antonio Lopez-Beltran

      Affiliations

    • Department of Pathology, Faculty of Medicine, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 957 218993; fax: +34 957 218229.

Received 4 November 2004 ,Revised 10 December 2004 ,Accepted 13 December 2004.

References 

  1. Ablashi DV, Bernbaum J, DiPaolo JA. Human herpesvirus 6 as a potential copathogen. Trends Microbiol. 1995;3:324–327
  2. Chan PK, Chan MY, Li WW, Chan DP, Cheung JL, Cheng AF. Association of human beta-herpesviruses with the development of cervical cancer: bystanders or cofactors. J. Clin. Pathol. 2001;54:48–53
  3. Chen M, Wang H, Woodworth CD, Lusso P, Berneman Z, Kingma D, et al. Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma. Am. J. Pathol. 1994;145:1509–1516
  4. Dockrell DH. Human herpesvirus 6: molecular biology and clinical features. J. Med. Microbiol. 2003;52:5–18
  5. Doniger J, Muralidhar S, Rosenthal LJ. Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate. Clin. Microbiol. Rev. 1999;12:367–382
  6. Furihata M, Inoue K, Ohtsuki Y, Hashimoto H, Terao N, Fujita Y. High-risk human papillomavirus infections and overexpression of p53 protein as prognostic indicators in transitional cell carcinoma of the urinary bladder. Cancer Res. 1993;53:4823–4827
  7. Gazzaniga P, Vercillo R, Gradilone A, Silvestri I, Gandini O, Napolitano M, et al. Prevalence of papillomavirus, Epstein-Barr virus, cytomegalovirus, and herpes simplex virus type 2 in urinary bladder cancer. J. Med. Virol. 1998;55:262–267
  8. Lopez-Beltran A, Escudero AL, Vicioso L, Munoz E, Carrasco JC. Human papillomavirus DNA as a factor determining the survival of bladder cancer patients. Br. J. Cancer. 1996;73:124–127
  9. Lopez-Beltran A, Escudero AL. Human papillomavirus and bladder cancer. Biomed. Pharmacother. 1997;51:252–257
  10. Swanton C, Jones N. Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products. Int. J. Exp. Pathol. 2001;82:3–13
  11. Kashanchi F, Araujo J, Doniger J, Muralidhar S, Hoch R, Khleif S, et al. Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene. 1997;14:359–367
  12. Romano N, Romano FM, Viviano E, Vitale F, Villafrate MR, Perna AM, et al. Rare association of human herpesvirus 6 DNA with human papillomavirus DNA in cervical smears of women with normal and abnormal cytologies. J. Clin. Microbiol. 1996;34:1589–1591
  13. Chen M, Popescu N, Woodworth C, Berneman Z, Corbellino M, Lusso P, et al. Human herpesvirus 6 infects cervical epithelial cells and transactivates human papillomavirus gene expression. J. Virol. 1994;68:1173–1178
  14. Yoshikawa T, Goshima F, Akimoto S, Ozaki T, Iwasaki T, Kurata T, et al. Human herpesvirus 6 infection of human epidermal cell line: pathogenesis of skin manifestations. J. Med. Virol. 2003;71:62–68
  15. Sauter G, Algaba F, Amin MB, Busch C, Cheville J, Gasser T, et al. Non invasive urothelial neoplasias. In:  Eble JN,  Sauter G,  Epstein JI,  Sesterhenn I editor. WHO Classification of Non-invasive Papillary Urothelial Tumors. World Health Organization Classification of Tumors. Pathology and Gentics of Tumors of the Urinary System and Male Genital Organs. Lyon: IARCC Press; 2004;p. 110–111
  16. Greene F, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al. AJCC Cancer Staging Manual. New York: Springer; 2002;pp. 335–340
  17. Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M, et al. Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J. Clin. Microbiol. 1991;29:367–372
  18. Dewhurst S, McIntyre K, Schnabel K, Hall CB. Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J. Clin. Microbiol. 1993;31:416–418
  19. Tran-Thanh D, Koushik A, Provencher D, Drouin P, Dubuc-Lissoir J, Gauthier P, et al. Detection of human herpes virus type 6 DNA in precancerous lesions of the uterine cervix. J. Med. Virol. 2002;68:606–610
  20. Kaku N, Kashima K, Daa T, Nakayama I, Yokoyama S. Herpes simplex infection in urothelial carcinoma. Virch. Arch. 2004;445:68–73

PII: S0304-3835(04)00987-5

doi: 10.1016/j.canlet.2004.12.014

Cancer Letters
Volume 230, Issue 1 , Pages 20-24 , 8 December 2005

Article Tools

* Image Usage & Resolution