Cancer Letters
Volume 229, Issue 1 , Pages 33-41 , 8 November 2005

Non-invasive detection of colorectal tumours by the combined application of molecular diagnosis and the faecal occult blood test

  • Nadine Kutzner

      Affiliations

    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany
    • ,
  • Ingrid Hoffmann

      Affiliations

    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany
    • ,
  • Christina Linke

      Affiliations

    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany
    • ,
  • Thomas Thienel

      Affiliations

    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany
    • ,
  • Marco Grzegorczyk

      Affiliations

    • Universität Dortmund, 44221 Dortmund, Germany
    • ,
  • Wolfgang Urfer

      Affiliations

    • Universität Dortmund, 44221 Dortmund, Germany
    • ,
  • Dirk Martin

      Affiliations

    • Katholisches Krankenhaus, 44379 Dortmund, Germany
    • ,
  • Günther Winde

      Affiliations

    • Klinik für Chirurgie, Klinikum Kreis Herford, 32045 Herford, Germany
    • ,
  • Thilo Traska

      Affiliations

    • Klinik für Chirurgie Marienhospital, 44625 Herne, Germany
    • ,
  • Gerd Hohlbach

      Affiliations

    • Klinik für Chirurgie Marienhospital, 44625 Herne, Germany
    • ,
  • Klaus-Michael Müller

      Affiliations

    • Berufsgenossenschaftlichen Kliniken Bergmannsheil, 44789 Bochum, Germany
    • ,
  • Cornelius Kuhnen

      Affiliations

    • Berufsgenossenschaftlichen Kliniken Bergmannsheil, 44789 Bochum, Germany
    • ,
  • Oliver Müller

      Affiliations

    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straβe 11, 44227 Dortmund, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 231 133 2158; fax: +49 231 133 2199.

Received 16 November 2004 ,Revised 10 December 2004 ,Accepted 12 December 2004.

References 

  1. Kahi CJ, Rex DK. Current and future trends in colorectal cancer screening. Cancer Metastasis Rev. 2004;23:137–144
  2. Frazier AL, Colditz GA, Fuchs CS, Kuntz KM. Cost-effectiveness of screening for colorectal cancer in the general population. J. Am. Med Assoc. 2000;284:1954–1961
  3. Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N. Engl. J. Med. 1993;328:1365–1371
  4. Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet. 1996;348:1472–1477
  5. Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O. Randomised study of screening for colorectal cancer with faecal-occult- blood test. Lancet. 1996;348:1467–1471
  6. Sidransky D, Tokino T, Hamilton SR, Kinzler KW, Levin B, Frost P, et al. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science. 1992;256:102–105
  7. Tagore KS, Levin TR, Lawson MJ. The evolution to stool DNA testing for colorectal cancer. Aliment. Pharmacol. Ther. 2004;19:1225–1233
  8. Calistri D, Rengucci C, Bocchini R, Saragoni L, Zoli W, Amadori D. Fecal multiple molecular tests to detect colorectal cancer in stool. Clin. Gastroenterol. Hepatol. 2003;1:377–383
  9. Ahlquist DA, Skoletsky JE, Boynton KA, Harrington JJ, Mahoney DW, Pierceall WE, et al. Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel. Gastroenterology. 2000;119:1219–1227
  10. Tagore KS, Lawson MJ, Yucaitis JA, Gage R, Orr T, Shuber AP, et al. Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia. Clin. Colorectal. Cancer. 2003;3:47–53
  11. Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, et al. sixth ed.. AJCC Cancer Staging Manual. XIV. 2002;
  12. Deuter R, Pietsch S, Hertel S, Muller O. A method for preparation of fecal DNA suitable for PCR. Nucleic Acids Res. 1995;23:3800–3801
  13. Kahmann S, Herter P, Kuhnen C, Muller KM, Muhr G, Martin D, et al. A non-radioactive protein truncation test for the sensitive detection of all stop and frameshift mutations. Hum. Mutat. 2002;19:165–172
  14. Traverso G, Shuber A, Olsson L, Levin B, Johnson C, Hamilton SR, et al. Detection of proximal colorectal cancers through analysis of faecal DNA. Lancet. 2002;359:403–404
  15. Traverso G, Shuber A, Levin B, Johnson C, Olsson L, Schoetz DJ, et al. Detection of APC mutations in fecal DNA from patients with colorectal tumors. N. Engl. J. Med. 2002;346:311–320
  16. Ahlquist DA, Shuber AP. Stool screening for colorectal cancer: evolution from occult blood to molecular markers. Clin. Chim. Acta. 2002;315:157–168

PII: S0304-3835(04)00979-6

doi: 10.1016/j.canlet.2004.12.011

Cancer Letters
Volume 229, Issue 1 , Pages 33-41 , 8 November 2005

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