Cancer Letters
Volume 229, Issue 1 , Pages 25-31, 8 November 2005

The CYP1A2-164A→C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans

  • Harald Moonen

      Affiliations

    • Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 43 388 1218; fax: +31 43 388 4146.
    • ,
  • Leopold Engels

      Affiliations

    • Department of Gastroenterology, Maasland Hospital, PO Box 5500, 6130 MB Sittard, The Netherlands
    • ,
  • Jos Kleinjans

      Affiliations

    • Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    • ,
  • Theo de Kok

      Affiliations

    • Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands

Received 25 October 2004; received in revised form 5 December 2004; accepted 8 December 2004.

Abstract 

Colorectal cancer (CRC) is believed to be related to the intake of processed meat and the formed heterocyclic aromatic amines (HCA) herein, which are metabolically activated by the enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2). The influence of genotypic and phenotypic variations for CYP1A2 and NAT2 on the risk for colorectal adenomas was investigated in 94 individuals at different risk of developing CRC. Significant associations were found between the CYP1A2-164A→C polymorphism (CYP1A2*1F) and the risk of colorectal adenomas, suggesting that the studied polymorphism plays an important role in CRC risk in humans.

Keywords: Heterocyclic aromatic amines, CYP1A2, Polymorphism, Colorectal cancer risk, Adenomas

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PII: S0304-3835(04)00975-9

doi:10.1016/j.canlet.2004.12.010

Cancer Letters
Volume 229, Issue 1 , Pages 25-31, 8 November 2005

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