Cancer Letters
Volume 227, Issue 1 , Pages 33-38 , 8 September 2005

Genetic mutual relationship between PTEN and p53 in gastric cancer

  • Eiji Oki

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 92 642 5948/5950; fax: +81 92 642 5951.
  • ,
  • Eriko Tokunaga

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Toshihiko Nakamura

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Naoyuki Ueda

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Motonori Futatsugi

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Kohjiro Mashino

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Manabu Yamamoto

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Masayuki Watanabe

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Masahiko Ikebe

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Yoshihiro Kakeji

      Affiliations

    • Center for the Integration of Advanced Medicine and Innovative Technology, Kyushu University Hospital 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Hideo Baba

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Yoshihiko Maehara

      Affiliations

    • Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

Received 28 October 2004 ,Revised 1 December 2004 ,Accepted 5 December 2004.

References 

  1. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 1997;15:356–362
  2. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275:1943–1947
  3. Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res. 1997;57:3935–3940
  4. Guldberg P, Thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res. 1997;57:3660–3663
  5. Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl Acad. Sci. USA. 1998;95:5246–5250
  6. Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res. 1997;57:4183–4186
  7. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res. 1997;57:5221–5225
  8. Maxwell GL, Risinger JI, Gumbs C, Shaw H, Bentley RC, Barrett JC, et al. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Res. 1998;58:2500–2503
  9. Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, et al. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res. 1997;57:4710–4713
  10. Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 1998;273:13375–13378
  11. Furnari FB, Lin H, Huang HS, Cavenee WK. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Natl Acad. Sci. USA. 1997;94:12479–12484
  12. Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, et al. Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res. 2000;60:3147–3151
  13. Fenoglio-Preiser CM, Wang J, Stemmermann GN, Noffsinger A. TP53 and gastric carcinoma: a review. Hum. Mutat. 2003;21:258–270
  14. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 1991;51:6304–6311
  15. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323–331
  16. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992;356:215–221
  17. Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, et al. Regulation of PTEN transcription by p53. Mol. Cell. 2001;8:317–325
  18. Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, Balmain A. Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene. 2003;22:8379–8385
  19. Maehara Y, Kakeji Y, Oda S, Baba H, Sugimachi K. Tumor growth patterns and biological characteristics of early gastric carcinoma. Oncology. 2001;61:102–112
  20. Oda S, Oki E, Maehara Y, Sugimachi K. Precise assessment of microsatellite instability using high resolution fluorescent microsatellite analysis. Nucl. Acids Res. 1997;25:3415–3420
  21. Maehara Y, Oda S, Sugimachi K. The instability within: problems in current analyses of microsatellite instability. Mutat. Res. 2001;461:249–263
  22. Gomyo Y, Osaki M, Kaibara N, Ito H. Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: analysis by fluorescence in situ hybridization (FISH) and PCR-SSCP. Int. J. Cancer. 1996;66:594–599
  23. Cho KR, Vogelstein B. Suppressor gene alterations in the colorectal adenoma-carcinoma sequence. J. Cell Biochem. 1992;(Suppl. 16G):137–141
  24. Tang B, Bottinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, et al. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency. Nat. Med. 1998;4:802–807
  25. Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 1998;396:177–180

PII: S0304-3835(04)00971-1

doi: 10.1016/j.canlet.2004.12.006

Cancer Letters
Volume 227, Issue 1 , Pages 33-38 , 8 September 2005