Genetic mutual relationship between PTEN and p53 in gastric cancer

Oki, Eiji; Tokunaga, Eriko; Nakamura, Toshihiko; Ueda, Naoyuki; Futatsugi, Motonori; Mashino, Kohjiro; Yamamoto, Manabu; Watanabe, Masayuki; Ikebe, Masahiko; Kakeji, Yoshihiro; Baba, Hideo; Maehara, Yoshihiko

doi:10.1016/j.canlet.2004.12.006

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Volume 227, Issue 1 , Pages 33-38, 8 September 2005

Genetic mutual relationship between PTEN and p53 in gastric cancer

Eiji Oki
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
- Corresponding author. Tel.: +81 92 642 5948/5950; fax: +81 92 642 5951.
Eriko Tokunaga
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Toshihiko Nakamura
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Naoyuki Ueda
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Motonori Futatsugi
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Kohjiro Mashino
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Manabu Yamamoto
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Masayuki Watanabe
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Masahiko Ikebe
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Yoshihiro Kakeji
- Center for the Integration of Advanced Medicine and Innovative Technology, Kyushu University Hospital 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Hideo Baba
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Yoshihiko Maehara
- Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

Received 28 October 2004; received in revised form 1 December 2004; accepted 5 December 2004.

Abstract

Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.

Keywords: PTEN, p53, Gastric cancer, Loss of heterozygosity