Cancer Letters
Volume 225, Issue 1 , Pages 53-59 , 8 July 2005

Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention

  • Kok Long Ang

      Affiliations

    • Laboratory of Tumor Phosphoproteomics, National Cancer Centre, Singapore
    • ,
  • Diong Lang Shi

      Affiliations

    • Laboratory of Tumor Phosphoproteomics, National Cancer Centre, Singapore
    • ,
  • Wong Wai Keong

      Affiliations

    • Department of General Surgery, Singapore General Hospital, Singapore
    • ,
  • Richard J. Epstein

      Affiliations

    • Laboratory of Tumor Phosphoproteomics, National Cancer Centre, Singapore
    • Department of Medicine, University of Hong Kong, Queen Mary Hospital, Room 404, Professorial Block, Pokfulam Road, Pokfulam, Hong Kong, People's Republic of China
    • Corresponding Author InformationCorresponding author. Address: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Room 404, Professorial Block, Pokfulam Road, Pokfulam, Hong Kong, People's Republic of China. Tel.: +852 2855 3994; fax: +852 2816 2863.

Received 11 October 2004 ,Revised 9 November 2004 ,Accepted 11 November 2004.

References 

  1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311–1315
  2. Axon A. Gastric cancer and Helicobacter pylori. Aliment. Pharmacol. Ther. 2002;16(suppl. 4):83–88
  3. Schandl L, Malfertheiner P, Ebert MP. Prevention of gastric cancer by Helicobacter pylori eradication: results from clinical intervention studies. Dig. Dis. 2002;20:18–22
  4. Kikuchi S. Epidemiology of Helicobacter pylori and gastric cancer. Gastric Cancer. 2002;5:6–15
  5. Takahashi S. Long-term Helicobacter pylori infection and the development of atrophic gastritis and gastric cancer in Japan. J. Gastroenterol. 2002;37(suppl. 13):24–27
  6. Zivny J, Wang TC, Yantiss R, Kim KH, Houghton J. Role of therapy or monitoring in preventing progression to gastric cancer. J. Clin. Gastroenterol. 2003;36(suppl. 5):50–60
  7. Roderick P, Davies R, Raftery J, Crabbe D, Pearce R, Patel P, et al. Cost-effectiveness of population screening for Helicobacter pylori in preventing gastric cancer and peptic ulcer disease, using simulation. J. Med. Screen. 2003;10:148–156
  8. Itoh M, Joh T, Imai S, Miyamoto T, Matsusako K, Iwai A, et al. Experimental and clinical studies on epidermal growth factor for gastric mucosal protection and healing of gastric ulcers. J. Clin. Gastroenterol. 1988;10(Suppl. 1):7–12
  9. Gregory H, Walsh S, Hopkins CR. The identification of urogastrone in serum, saliva and gastric juice. Gastroenterology. 1979;77:313–318
  10. Wong BC, Wang WP, So WH, Shin VY, Wong WM, Fung FM, et al. Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Aliment. Pharmacol. Ther. 2001;15:1459–1465
  11. Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ, Wiley HS. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc. Natl Acad. Sci. USA. 1999;96:6235–6240
  12. Wallasch C, Crabtree JE, Bevec D, Robinson PA, Wagner H, Ullrich A. Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem. Biophys. Res. Commun. 2002;295:695–701
  13. Miyazaki Y, Hiraoka S, Tsutsui S, Kitamura S, Shinomura Y, Matsuzawa S. Epidermal growth factor receptor mediates stress-induced expression of its ligands in rat gastric epithelial cells. Gastroenterology. 2001;120:108–116
  14. Coyle WJ, Sedlack RE, Nemec R, Peterson R, Duntemann T, Murphy S, et al. Eradication of Helicobacter pylori normalizes elevated levels of EGF and its receptor. Am. J. Gastroenterol. 1999;94:2885–2889
  15. Wong BC, Wang WP, So WH, Shin VY, Wong WM, Fung FM, et al. EGF and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Aliment. Pharmacol. Ther. 2001;15:1459–1465
  16. Gibson S, Tu S, Oyer R, Anderson SM, Johnson GL. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis: requirement for Akt activation. J. Biol. Chem. 1999;274:17612–17618
  17. Akagi M, Kawaguchi M, Liu W, McCarty MF, Takeda A, Fan F, et al. Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. Br. J. Cancer. 2003;88:796–802
  18. Staal SP. Molecular cloning of the Akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc. Natl Acad. Sci. USA. 1987;84:5034–5037
  19. Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes M, et al. The effects of the novel reversible EGFR/ErbB2 tyrosine kinase inhibitor GW2016 on the growth of nomral and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. 2001;1:85–94
  20. Osaki M, Kase S, Adachi K, Takeda A, Hashimoto K, Ito H. Inhibition of the P!3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line MKN-45. J. Cancer Res. Clin. Oncol. 2004;130:8–14
  21. Nam SY, Jung GA, Hur GC, Chung HY, Kim WH, Seol DW, et al. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer Sci. 2003;94:1066–1073
  22. Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, et al. Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma. Int. J. Cancer. 2003;104:318–327
  23. Kang YH, Lee HS, Kim WH. Promoter methylation and silencing of PTEN in gastric cancer. Lab. Invest. 2002;82:285–291
  24. Epstein RJ, Druker BJ, Roberts TM, Stiles CD. Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc. Natl Acad. Sci. USA. 1992;89:10435–10439
  25. Ouyang X, Gulliford T, Doherty A, Huang G, Epstein RJ. Detection of ErbB2 oversignaling in a majority of breast cancers using phosphorylation-state-specific antibodies. Lancet. 1999;353:1591–1592
  26. Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?. J. Cell Sci. 2001;114:2903–2910
  27. Zhang H, Zha X, Tan Y, Hornbeck PV, Mastrangelo AJ, Alessi DR, et al. Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. J. Biol. Chem. 2002;277:39379–39387
  28. Manoukian AS, Woodgettt JR. Role of glycogen synthase kinase-3 in cancer: regulation by Wnt and other signaling pathways. Adv. Cancer Res. 2002;84:203–229
  29. Boylan JM, Anand P, Gruppuso PA. Ribosomal protein S6 phosphorylation and function during late-gestation liver development in the rat. J. Biol. Chem. 2001;276:44457–44463
  30. Lim YP, Diong LS, Qi R, Druker BJ, Epstein RJ. Phosphoproteomic fingerprinting of growth factor signaling and anticancer drug action in human tumor cells. Mol. Cancer Ther. 2003;2:1369–1377
  31. For the Southeast Sweden Breast Cancer GroupPerez-Tenorio G, Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br. J. Cancer. 2002;86:540–545
  32. Schmitz KJ, Otterbach R, Callies R, Levkau B, Holscher M, Hoffman O, et al. Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases. Mod. Pathol. 2004;
  33. Nam SY, Lee HS, Jung G, Choi J, Cho SJ, Kim MK, et al. Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis. APMIS. 2003;111:1105–1113
  34. Mirza AM, Kohn AD, Roth RA, McMahon M. Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB. Cell Growth Differ. 2000;11:279–292
  35. Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, Lynch HT, et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis. 2002;23:201–205
  36. Husain SS, Szabo IL, Tamawski AS. NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action. Am. J. Gastroenterol. 2002;97:542–553
  37. Zhou XM, Wong BC, Fan XM, Zhang HB, Lin MC, Kung HF, et al. Nonsteroidal antiinflammatory drugs induce apoptosis in gastric cancer cells through upregulation of Bax and Bak. Carcinogenesis. 2001;22:1393–1397
  38. Nam DH, Park K, Park C, Im YH, Kim MH, Lee S, et al. Intracranial inhibition of glioma cell growth by cyclooxygenase inhibitor celecoxib. Oncol. Rep. 2004;11:263–268
  39. Baoping Y, Guoyong H, Jieping Y, Zongxue R, Hesheng L. COX-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cells. Dig. Dis. Sci. 2004;49:948–953
  40. Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, et al. PI3K/Akt signaling represents a major COX-2-independent target for celecoxib in prostate cancer cells. Cancer Res. 2004;64:1444–1451
  41. Gao S, Yu BP, Li Y, Dong WG, Luo HS. Antiproliferative effect of octreotide on gastric cancer cells by inhibition of Akt/PKB and telomerase. World J. Gastroenterol. 2003;9:2362–2365
  42. Sheu BS, Yang HB, Sheu AM, Huang AH, Wu JJ. Higher gastric cyclooxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients. Clin. Cancer Res. 2003;9:5245–5251
  43. Forman D. The prevalence of Helicobacter pylori infection in gastric cancer. Aliment. Pharmacol. Ther. 1995;9(Suppl. 2):71–76
  44. Huang JQ, Hunt RH. The evolving epidemiology of Helicobacter pylori infection in gastric cancer. Can. J. Gastroenterol. 2003;17:18–20
  45. Hua J, Zheng PY, Yeoh KG, Ho B. The status of the cagA gene does not predict H. pylori-associated peptic ulcer in Singapore. Microbios. 2000;102:113–120
  46. Doll R. Nature and nurture: possibilities for cancer control. Carcinogenesis. 1996;17:177–184
  47. Shiao YH, Rugge M, Correa P, Lehmann HP, Scheer WD. p53 alteration in gastric precancerous lesions. Am. J. Pathol. 1994;144:511–517

PII: S0304-3835(04)00882-1

doi: 10.1016/j.canlet.2004.11.021

Cancer Letters
Volume 225, Issue 1 , Pages 53-59 , 8 July 2005

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