« Previous
Next »
Cancer Letters
Volume 227, Issue 1
, Pages 1-7
, 8 September 2005
BRCA1 in breast and ovarian cancer predisposition
References
- Linkage of early-onset familial breast cancer to chromosome 17q21. Science. 1990;250(4988):1684–1689
- A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266(5182):66–71
- . Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. Am. J. Hum. Genet. 1993;52(4):678–701
- BRCA1 mutations in primary breast and ovarian carcinomas. Science. 1994;266(5182):120–122
- Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. Nat. Genet. 1995;9(4):439–443
- . BRCA1-associated tumorigenesis: what have we learned from knockout mice?. Trends Genet. 2001;17(10):S18–S22
- . Molecular functions of BRCA1 in the DNA damage response. Cancer Biol. Ther. 2004;3(6):521–527
- . BRCA1 and BRCA2: 1994 and beyond. Nat. Rev. Cancer. 2004;4(9):665–676
- . Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 1997;90(3):425–435
- Location of BRCA1 in human breast and ovarian cancer cells [letter; comment]. Science. 1996;272(5258):123–126
- . Brca1 controls homology-directed DNA repair. Mol. Cell. 1999;4(4):511–518
- A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. Oncogene. 2002;21(9):1401–1410
- Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Res. 2001;61(1):270–277
- . Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res. 2002;62(14):3966–3970
- . BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J. Biol. Chem. 1999;274(26):18808–18812
- . BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J. Biol. Chem. 2002;277(32):28641–28647
- A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998;17(24):3115–3124
- . The DNA damage response: putting checkpoints in perspective. Nature. 2000;408(6811):433–439
- The ring heterodimer brca1–bard1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J. Biol. Chem. 2001;276(18):14537–14540
- . Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc. Natl Acad. Sci. USA. 2001;98(9):5134–5139
- BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell. 2000;102(2):257–265
- . BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl Acad. Sci. USA. 1999;96(9):4983–4988
- BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell. 2001;105(1):149–160
- . BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene. 1998;17(15):1939–1948
- . Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl Acad. Sci. USA. 1996;93(24):13595–13599
- . Transcriptional activation by BRCA1 [letter; comment]. Nature. 1996;382(6593):678–679
- . Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999;285(5433):1576–1579
- . BRCA1 associates with processive RNA polymerase II. J. Biol. Chem. 2003;278(52):52012–52020
- BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl Acad. Sci. USA. 1997;94(11):5605–5610
- . BRCA1: exploring the links to transcription. Trends Biochem. Sci. 2000;25(10):469–474
- . The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr. Opin. Cell Biol. 2003;15(3):345–350
- . Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. J. Biol. Chem. 1999;274(9):5659–5665
- Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 1996;14(4):430–440
- . Ubiquitin enters the new millennium. Mol. Cell. 2001;8(3):499–504
- . Ubiquitin: roles in protein modification and breakdown. Cell. 1983;34(1):11–12
- . Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 2001;70:503–533
- . RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA. 1999;96(20):11364–11369
- . The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity. Curr. Opin. Genet. Dev. 2002;12(1):86–91
- . BRCA1-independent ubiquitination of FANCD2. Mol. Cell. 2003;12(1):247–254
- . Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. Eur. Mol. Biol. Organ. J. 2002;21(24):6755–6762
- . Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J. Biol. Chem. 2002;277(24):22085–22092
- Nucleophosmin/B23 is a candidate substrate for the BRCA1–BARD1 ubiquitin ligase. J. Biol. Chem. 2004;279(30):30919–30922
- BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol. Cell Biol. 2004;24(19):8457–8466
- . Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol. Cell. 2003;12(5):1087–1099
- . Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. J. Biol. Chem. 2004;279(32):33909–33918
- . Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 2000;275(13):9390–9395
- . A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 2000;10(15):886–895
- . The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J. Biol. Chem. 2003;278(37):34743–34746
- Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase. J. Biol. Chem. 2004;279(6):3916–3924
- . BRCA1 protein products… Functional motifs… [letter]. Nat. Genet. 1996;13(3):266–268
- . A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. Fed. Am. Soc. Exp. Biol. J. 1997;11(1):68–76
- . From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. Fed. Eur. Biochem. Soc. Lett. 1997;400(1):25–30
- . Understanding germ-line mutations in BRCA1. Cancer Biol. Ther. 2004;3(6):515–520
- . Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J. Biol. Chem. 2003;278(52):52914–52918
- . BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 2003;302(5645):636–639
- . The BRCT domain is a phospho-protein binding domain. Science. 2003;302(5645):639–642
- . Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nat. Struct. Mol. Biol. 2004;
- . Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat. Struct. Mol. Biol. 2004;
- . Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (Cambridge). 2004;12(7):1137–1146
- . Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol. Cell. 2004;14(3):405–412
- . BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels. Mol. Cell Biol. 2004;24(16):6947–6956
- . Genetic analysis of BRCA1 function in a defined tumor cell line. Mol. Cell. 1999;4(6):1093–1099
- Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell Biol. 1997;17(1):444–452
- . Identification of a functional nuclear export sequence in BRCA1. J. Biol. Chem. 2000;275(49):38589–38596
- . Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. Exp. Cell Res. 2004;293(1):14–21
- . Cancer incidence in BRCA1 mutation carriers. J. Natl Cancer Inst. 2002;94(18):1358–1365
- . BRCA1: the enigma of tissue-specific tumor development. Trends Genet. 2003;19(6):312–315
- Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene. 2001;20(1):77–87
- . BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc. Natl Acad. Sci. USA. 2001;98(17):9587–9592
- . The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell. 2002;1:129–132
PII: S0304-3835(04)00864-X
doi: 10.1016/j.canlet.2004.11.006
© 2004 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Cancer Letters
Volume 227, Issue 1
, Pages 1-7
, 8 September 2005
