Cancer Letters
Volume 224, Issue 1 , Pages 45-52 , 16 June 2005

Inhibition of NMU-induced mammary tumorigenesis by dietary soy

  • Rosalia C.M. Simmen

      Affiliations

    • Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    • Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children's Nutrition Center, Little Rock, AR, USA. Tel.: +1 501 364 2849; fax: +1 501 364 3161.
  • ,
  • Renea R. Eason

      Affiliations

    • Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
  • ,
  • S. Reneé Till

      Affiliations

    • Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
  • ,
  • Leon Chatman Jr.

      Affiliations

    • Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
  • ,
  • Michael C. Velarde

      Affiliations

    • Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
  • ,
  • Yan Geng

      Affiliations

    • Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    • Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
  • ,
  • Sohelia Korourian

      Affiliations

    • Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
  • ,
  • Thomas M. Badger

      Affiliations

    • Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    • Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Received 4 October 2004 ,Revised 30 October 2004 ,Accepted 1 November 2004.

References 

  1. Hodgson SV, Morrison PJ, Irving M. Breast cancer genetics: unsolved questions and open perspective in an expanding field. Am. J. Med. Genet. 2004;129C:56–64
  2. Garinis GA, Patrinos GP, Spanakis NE, Menounos PG. DNA hypermethylation: when tumor suppressor genes go silent. Hum. Genet. 2002;111:115–127
  3. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 2002;3:415–428
  4. Robson ME, Boyd J, Borgen PI, Cody HS. Hereditary breast cancer. Curr. Probl. Surg. 2001;38:377–480
  5. Cipollinni G, Tommasi S, Paradiso A, Aretini P, Bonatti F, Brunetti I, et al. Genetic alterations in hereditary breast cancer. Ann. Oncol. 2004;15(Suppl. 1):7–13
  6. McMahon B, Cole P, Brown J. Etiology of human breast cancer: a review. J. Natl Cancer Inst. 1973;50:21–42
  7. Russo J, Rivera R, Russo H. Influence of age and parity on the development of the human breast. Breast Cancer Res. Treat. 1992;23:211–218
  8. Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC. Adolescent and adult soy intake and risk of breast cancer in Asian–Americans. Carcinogenesis. 2002;21:1491–1496
  9. Russo J, Russo IH. Influence and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res. 1980;40:2677–2687
  10. Sivaraman L, Hilsenbeck SG, Zhong L, Gay J, Conneely OM, Medina D, et al. Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation. J. Endocrinol. 2001;171:75–83
  11. D'Cruz CM, Moody SE, Master SR, Hartman JL, Keiper EA, Imielinski MB, et al. Persistent parity-induced changes in growth factors, TGF-β3, and differentiation in the rodent mammary gland. Mol. Endocrinol. 2002;16:2034–2051
  12. Geske FJ, Nelson AC, Lieberman R, Strange R, Sun T, Gerschenson LE. DNA repair is activated in early stages of p53-induced apoptosis. Cell Death Differ. 2000;7:393–401
  13. Hakkak R, Korourian S, Shelnutt SR, Lensing S, Ronis MJ, Badger TM. Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol. Biomarkers Prev. 2000;9:113–117
  14. Rowlands JC, He L, Hakkak R, Ronis MJJ, Badger TM. Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. J. Nutr. 2001;131:3281–3287
  15. Thompson HJ, Adlakha H. Dose-responsive induction of mammary gland carcinomas by the intraperitoneal injection of 1-methyl-1-nitrosourea. Cancer Res. 1991;51:3411–3415
  16. R.R. Eason, M.C. Velarde, L. Chatman, Jr., S.R. Till, Y. Geng, M. Ferguson, et al., Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development, J. Nutr. 135 (2005) in press.
  17. Revillion F, Bonneterre J, Peyrat JP. ERBB2 oncogene in himan breast cancer and its clinical significance. Eur. J. Cancer. 1998;34:791–808
  18. Esteva FJ, Hortobagyi GN. Prognostic molecular markers in early breast cancer. Breast Cancer Res. 2004;6:109–118
  19. Oren M. Decision making by p53: life, death and cancer. Cell Death Differ. 2003;10:431–442
  20. Ismail PM, Amato P, Soyal SM, DeMayo FJ, Conneely OM, O'Malley BW, et al. Progesterone involvement in breast development and tumorigenesis-as revealed by progesterone “knockout” and “knockin” mouse models. Steroids. 2003;68:779–787
  21. Eason RR, Velarde M, Chatman L, Till SR, Geng Y, Ferguson M, et al. Dietary exposure to soy and whey proteins alters rat mammary gland gene expression during development. Fed. Am. Soc. Exp. Biol. J. 2004;18(4):A356.10
  22. Lydon JP, Ge G, Kittrell FS, Medina D, O'Malley BW. Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res. 1999;59:4276–4284
  23. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification in HER-2/neu oncogene. Science. 1987;235:177–182
  24. Zeillinger R, Kury F, Czerwenka K, Kubista E, Sliutz G, Knogler W, et al. HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer. Oncogene. 1989;4:109–114
  25. Lange CA, Richer JK, Horwitz KB. Hypothesis: progesterone primes breast cancer cells for cross-talk with proliferative or anti-proliferative signals. Mol. Endocrinol. 1999;13:829–836
  26. Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, et al. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol. Endocrinol. 1999;13:787–796
  27. Medina D, Peterson LE, Moraes R, Gay J. Short-term exposure to estrogen and progesterone induces partial protection against N-nitroso-N-methylurea-induced mammary tumorigenesis in Wistar-Furth rats. Cancer Lett. 2001;169:1–6
  28. Schmidtt CA. Senescence, apoptosis and therapy-cutting the lifelines of cancer. Nature Rev. Cancer. 2003;3:286–295
  29. Lu L-JW, Anderson KE, Grady JJ, Kohen F, Nagamani M. Decreased ovarian hormones during a soya diet: implications for breast cancer prevention. Cancer Res. 2000;60:4112–4121
  30. Nandi S, Guzman RC, Yang J. Hormones and mammary carcinogenesis in mice, rats and humans: a unifying hypothesis. Proc. Natl Acad. Sci. USA. 1995;92:3650–3657

 Funds for this research were provided by USDA-CRIS-6251-5100002-06S to the Arkansas Children's Nutrition Center.

PII: S0304-3835(04)00859-6

doi: 10.1016/j.canlet.2004.11.009

Cancer Letters
Volume 224, Issue 1 , Pages 45-52 , 16 June 2005