The DNA repair gene ERCC2/XPD polymorphism Arg 156Arg (A22541C) and risk of lung cancer in a Chinese population

Yin, Jiaoyang; Li, Jicheng; Ma, Yegang; Guo, Li; Wang, Huiwen; Vogel, Ulla

doi:10.1016/j.canlet.2004.10.032

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Volume 223, Issue 2 , Pages 219-226, 8 June 2005

The DNA repair gene ERCC2/XPD polymorphism Arg 156Arg (A22541C) and risk of lung cancer in a Chinese population

Jiaoyang Yin
- Institute of Cell Biology, Zhejiang University, Hangzhou (310031), Zhejiang Province, People's Republic of China
- Department of Medical Genetics, Shenyang Medical College, Shenyang (110034), Liaoning Province, People's Republic of China
Jicheng Li
- Institute of Cell Biology, Zhejiang University, Hangzhou (310031), Zhejiang Province, People's Republic of China
- Corresponding author. Tel.: +86 571 8721 7145; fax: +86 571 8721 7145.
Yegang Ma
- Department of Thoracic Surgery, Liaoning Tumor Hospital, Shenyang (110042), Liaoning Province, People's Republic of China
Li Guo
- Department of Medical Genetics, Shenyang Medical College, Shenyang (110034), Liaoning Province, People's Republic of China
Huiwen Wang
- Department of Medical Genetics, Shenyang Medical College, Shenyang (110034), Liaoning Province, People's Republic of China
Ulla Vogel
- National Institute of Occupational Health, Lerso Parkalle 105, DK-2100 Copenhagen O, Denmark

Received 7 September 2004; received in revised form 22 October 2004; accepted 24 October 2004.

Abstract

To determine the effect of the DNA repair gene XPD Arg156Arg polymorphism on the risk of lung cancer in a North-Eastern Chinese population, a hospital-based case-control study was designed consisting of 149 newly diagnosis subjects with lung cancer and 137 cancer-free control subjects matched on age (±3 years), gender and ethnicity. In the whole study group, XPD Arg156Arg was not associated with risk of lung cancer. In stratified analyses, the variant A-allele of XPD Arg156Arg was associated with increased risk of adenocarcinoma of lung (AA/AC versus CC; adjusted OR=1.65; 95% CI=1.09–2.50) (P=0.02). Furthermore, the presence of one or two variant A-alleles was associated with increased risk for lung cancer (OR=2.49; 95% CI=1.10–5.64) (P=0.03) and adenocarcinoma of lung (OR=5.60; 95% CI=1.52–20.56) (P=0.005) among never-smokers only. These results suggest a possible gene–environment interaction. This is the first study to report a significant association of XPD Arg156Arg with risk of lung cancer.

Keywords: ERCC2/XPD Arg156Arg (A22541C), Genetic polymorphism, Lung cancer, Chinese population