Cancer Letters
Volume 223, Issue 2 , Pages 211-218 , 8 June 2005

Actinonin induces apoptosis in U937 leukemia cells

  • Mirjana Grujic

      Affiliations

    • Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia
    • Department of Molecular Biosciences, Swedish University of Agricultural Sciences, BMC, Box 575, 75123 Uppsala, Sweden
    • Corresponding Author InformationCorresponding author. Present address: Department of Molecular Biosciences, Swedish University of Agricultural Sciences, BMC, Box 575, 75123 Uppsala, Sweden. Tel.: +46 18 471 4192; fax: +46 18 55 0762.
    • ,
  • Tina Zavasnik-Bergant

      Affiliations

    • Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia
    • ,
  • Gunnar Pejler

      Affiliations

    • Department of Molecular Biosciences, Swedish University of Agricultural Sciences, BMC, Box 575, 75123 Uppsala, Sweden
    • ,
  • Metka Renko

      Affiliations

    • Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia

Received 30 September 2004 ,Revised 22 October 2004 ,Accepted 24 October 2004.

References 

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  2. Chen DZ, Patel DV, Hackbarth CJ, Wang W, Dreyer G, Young DC, et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000;39:1256–1262
  3. Umezawa H, Aoyagi T, Tanaka T, Suda H, Okuyama A, Naganawa H, et al. Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes. J. Antibiot. (Tokyo). 1985;38:1629–1630
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  13. Grujic M, Renko M. Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions. Cancer Lett. 2002;182:113–119
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  15. Giannakis C, Forbes IJ, Zalewski PD. Ca2+/Mg(2+)-dependent nuclease: tissue distribution, relationship to inter-nucleosomal DNA fragmentation and inhibition by Zn2+. Biochem. Biophys. Res. Commun. 1991;181:915–920
  16. Kimura C, Zhao QL, Kondo T, Amatsu M, Fujiwara Y. Mechanism of UV-induced apoptosis in human leukemia cells: roles of Ca2+/Mg(2+)-dependent endonuclease, caspase-3, and stress-activated protein kinases. Exp. Cell Res. 1998;239:411–422
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PII: S0304-3835(04)00841-9

doi: 10.1016/j.canlet.2004.10.048

Cancer Letters
Volume 223, Issue 2 , Pages 211-218 , 8 June 2005

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