Cancer Letters
Volume 224, Issue 1 , Pages 111-116 , 16 June 2005

The PPARγ K422Q mutation does not contribute to troglitazone inefficiency in colon cancer treatment

  • Delphine Bouancheau

      Affiliations

    • INSERM U539, Faculté de Médecine, UFR de Médecine,1 rue Gaston Veil, Nantes cedex 44035, France
    • ,
  • Bruno Buecher

      Affiliations

    • Service de Gastroentérologie, CHU Hotel-Dieu, Nantes, France
    • ,
  • Anne Jarry

      Affiliations

    • INSERM U539, Faculté de Médecine, UFR de Médecine,1 rue Gaston Veil, Nantes cedex 44035, France
    • ,
  • Barbara Simon

      Affiliations

    • Laboratoire d'étude du Polymorphisme de l'ADN, Faculté de Médecine, Nantes, France
    • ,
  • Damien Masson

      Affiliations

    • INSERM U539, Faculté de Médecine, UFR de Médecine,1 rue Gaston Veil, Nantes cedex 44035, France
    • ,
  • Elisabeth Cassagnau

      Affiliations

    • INSERM U539, Faculté de Médecine, UFR de Médecine,1 rue Gaston Veil, Nantes cedex 44035, France
    • ,
  • Richard Hamelin

      Affiliations

    • INSERM U434, CEPH, Paris, France
    • ,
  • Christian L. Laboisse

      Affiliations

    • INSERM U539, Faculté de Médecine, UFR de Médecine,1 rue Gaston Veil, Nantes cedex 44035, France
    • ,
  • Stéphane Bézieau

      Affiliations

    • Laboratoire d'étude du Polymorphisme de l'ADN, Faculté de Médecine, Nantes, France
    • ,
  • Marc G. Denis

      Affiliations

    • INSERM U539, Faculté de Médecine, UFR de Médecine,1 rue Gaston Veil, Nantes cedex 44035, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 240 08 40 05; fax: +33 240 08 39 91.

Received 31 August 2004 ,Revised 25 September 2004 ,Accepted 1 October 2004.

References 

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  2. Michalik L, Desvergne B, Wahli W. Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat. Rev. Cancer. 2004;4:61–70
  3. Sarraf P, Mueller E, Jones D, King FJ, Deangelo DJ, Partridge JB, et al. Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat. Med. 1998;4:1046–1052
  4. Tanaka T, Kohno H, Yoshitani S, Takashima S, Okumura A, Murakami A, et al. Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res. 2001;61:2424–2428
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  11. Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, et al. Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. Proc. Natl Acad. Sci. USA. 2000;97:10990–10995
  12. Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, et al. APC-dependent suppression of colon carcinogenesis by PPAR gamma. Proc. Natl Acad. Sci. USA. 2002;99:13771–13776
  13. Ohnuki Y, Reddel RR, Bates SE, Lehman TA, Lechner JF, Harris CC. Chromosomal changes and progressive tumorigenesis of human bronchial epithelial cell lines. Cancer Genet. Cytogenet. 1996;92:99–110
  14. Pollock PM, Walker GJ, Glendening JM, Que Noy T, Bloch NC, Fountain JW, et al. PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines. Melanoma Res. 2002;12:565–575

PII: S0304-3835(04)00779-7

doi: 10.1016/j.canlet.2004.10.011

Cancer Letters
Volume 224, Issue 1 , Pages 111-116 , 16 June 2005

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