Cancer Letters
Volume 224, Issue 1 , Pages 105-109, 16 June 2005

PTEN and Egr-1 expression in thyroid proliferative lesions

  • Carla Di Loreto

      Affiliations

    • Anatomic Pathology, University of Udine, Udine, Italy
    • ,
  • Gianluca Tell

      Affiliations

    • Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    • ,
  • Marta Pestrin

      Affiliations

    • Clinical Oncology, University of Udine, Udine, Italy
    • ,
  • Maura Pandolfi

      Affiliations

    • Anatomic Pathology, University of Udine, Udine, Italy
    • ,
  • Giuseppe Damante

      Affiliations

    • Genetics, University of Udine, Udine, Italy
    • ,
  • Fabio Puglisi

      Affiliations

    • Clinical Oncology, University of Udine, Udine, Italy
    • Corresponding Author InformationCorresponding author. Address: Clinica Oncologica, Policlinico Universitario, Piazzale SM Misericordia, I-33100, Udine, Italy. Tel.: +39 432 559304; fax: +39 432 559305.

Received 29 July 2004; received in revised form 28 September 2004; accepted 1 October 2004.

Abstract 

PTEN is a tumor suppressor gene that inhibits cell cycle progression. Recent data support that PTEN transcription is upregulated by Egr-1. The present study evaluated the immunohistochemical expression of PTEN and Egr-1 in normal thyroid and in its benign and malignant proliferative lesions. PTEN expression was cytoplasmic. The median percentage of normal cells with positive staining was 97.5%. It was similar in nodular hyperplasia, adenoma and papillary carcinoma. Follicular and undifferentiated carcinoma presented a significant decrease in the percentage of positive cells (P=0.027 and P=0.004). Egr-1 expression was nuclear. The median percentage of positivity was similar in normal tissue (29.75%), nodular hyperplasia (30.5%) and papillary carcinoma (28.25%). Adenomas, follicular carcinomas and undifferentiated carcinomas showed a significant decrease of nuclear positivity (P=0.001; P=0.001 and P=0.004, respectively).

Keywords: PTEN, Egr-1, Thyroid, Immunohistochemistry

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PII: S0304-3835(04)00778-5

doi:10.1016/j.canlet.2004.10.014

Cancer Letters
Volume 224, Issue 1 , Pages 105-109, 16 June 2005

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