Cancer Letters
Volume 224, Issue 1 , Pages 93-103 , 16 June 2005

The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression

  • Grit Kasper

      Affiliations

    • metaGen Pharmaceuticals GmbH i.L., Oudenarderstr. 16, 13347 Berlin, Germany
    • ,
  • Anke Vogel

      Affiliations

    • metaGen Pharmaceuticals GmbH i.L., Oudenarderstr. 16, 13347 Berlin, Germany
    • ,
  • Irina Klaman

      Affiliations

    • Emil von Behring Hospital, Institute of Pathology, Waltershöferstr. 11, 14165 Berlin, Germany
    • ,
  • Jörn Gröne

      Affiliations

    • Department of Vascular and Thoraric Surgery, Campus Benjamin-Franklin, University Hospital Charité, Hindenburgdamm 30, 12200 Berlin, Germany
    • ,
  • Iver Petersen

      Affiliations

    • Institute of Pathology, Campus Mitte, University Hospital Charité, Schumannstr. 20/21, 10117 Berlin, Germany
    • ,
  • Birgit Weber

      Affiliations

    • metaGen Pharmaceuticals GmbH i.L., Oudenarderstr. 16, 13347 Berlin, Germany
    • ,
  • Esmeralda Castaños-Vélez

      Affiliations

    • metaGen Pharmaceuticals GmbH i.L., Oudenarderstr. 16, 13347 Berlin, Germany
    • ,
  • Eike Staub

      Affiliations

    • Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195, Berlin, Germany
    • ,
  • Detlev Mennerich

      Affiliations

    • Research Laboratories of Schering AG, CRBA Oncology, Apoptosis and Signal Transduction, Müllerstr. 178, 13342 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 304 6819 2189; fax: +49 304 6899 2189.

Received 8 August 2004 ,Revised 1 October 2004 ,Accepted 1 October 2004.

References 

  1. Adra CN, Zhu S, Ko JL, Guillemot JC, Cuervo AM, Kobayashi H, et al. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Genomics. 1996;35:328–337
  2. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997;25:3389–3402
  3. Cabrita MA, Hobman TC, Hogue DL, King KM, Cass CE. Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes. Cancer Res. 1999;59:4890–4897
  4. Goodstadt L, Ponting CP. CHROMA: consensus-based colouring of multiple alignments for publication. Bioinformatics. 2001;17:845–846
  5. Hayami Y, Iiga S, Nakazawa N, Kato M, Komatsu H, Miura I, et al. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. Leukemia. 2003;17:1650–1657
  6. He J, Shao G, Zhou R. Effects of the novel gene, LAPTM4B, highly expression in hepatocellular carcinoma on cell proliferation and tumorigenesis of NIH3T3 cells. Beijing Da Xue Xue Bao. 2003;35:348–352
  7. Hogue DL, Kerby L, Ling V. A mammalian lysosomal membrane protein confers multidrug resistance upon expression in Saccharomyces cerevisiae. J. Biol. Chem. 1999;274:12877–12882
  8. Hogue DL, Nash C, Ling V, Hobman TC. Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes. Biochem. J. 2002;365:721–730
  9. Hunziker W, Geuze HJ. Intracellular trafficking of lysosomal membrane proteins. Bioessays. 1996;18:379–389
  10. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acid Res. 2003;31:e15
  11. Jeanmougin F, Thompson JD, Gouy M, Higgins DG, Gibson TJ. Multiple sequence alignment with Clustal X. Trends Biochem. Sci. 1998;23:403–405
  12. Krogh A, Larsson B, von Heijne G, Sonnhammer EL. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 2001;305:567–580
  13. Liu J, Zhou R, Zhang N, Rui J, Jin C. Biological function of a novel gene overexpressed in human hepatocellular carcinoma. Chin. Med. J. (Engl.). 2000;113:881–885
  14. Liu X, Zhou R, Zhang Q, Zhang Y, Shao G, Jin Y, et al. Identification and characterization of LAPTM4B encoded by a human hepatocellular carcinoma-associated novel gene. Beijing Da Xue Xue Bao. 2003;35:340–347
  15. Luo L, Salunga RC, Guo H, Bittner A, Joy KC, Galindo JE, et al. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nat. Med. 1999;5:117–122
  16. Moller S, Croning MD, Apweiler R. Evaluation of methods for the prediction of membrane spanning regions. Bioinformatics. 2001;17:646–653
  17. Muller-Tidow C, Metzger R, Kugler K, Diederichs S, Idos G, Thomas M, et al. Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. Cancer Res. 2001;61:647–653
  18. Shao GZ, Zhou RL, Zhang QY, Zhang Y, Liu JJ, Rui JA, et al. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. Oncogene. 2003;22:5060–5069

PII: S0304-3835(04)00777-3

doi: 10.1016/j.canlet.2004.10.004

Cancer Letters
Volume 224, Issue 1 , Pages 93-103 , 16 June 2005

Article Tools

* Image Usage & Resolution