Cancer Letters
Volume 222, Issue 1 , Pages 49-55, 10 May 2005

Electro-sensitisation of mammalian cells and tissues to ultrasound: a novel tumour treatment modality

  • A.M. Rollan Haro

      Affiliations

    • Gendel Ltd, Science Innovation Centre, University of Ulster, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK
    • ,
  • A. Smyth

      Affiliations

    • Gendel Ltd, Science Innovation Centre, University of Ulster, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK
    • ,
  • P. Hughes

      Affiliations

    • School of Biomedical Sciences, University of Ulster, Cromore Rd, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK
    • ,
  • C.N. Reid

      Affiliations

    • Gendel Ltd, Science Innovation Centre, University of Ulster, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK
    • ,
  • A.P. McHale

      Affiliations

    • School of Biomedical Sciences, University of Ulster, Cromore Rd, Coleraine, Co. Londonderry, BT52 1SA, Northern Ireland, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 2870 324616; fax: +44 2870 324965.

Received 22 July 2004; received in revised form 15 September 2004; accepted 21 September 2004.

Abstract 

This study demonstrates that mammalian cell targets (erythrocytes and tumour cells) may be sensitised to ultrasound using electric pulses and this combination treatment results in destruction of those cells in vitro. It further demonstrates that when a tumour mass is treated in vivo using combined electric field and ultrasound therapy, significant retardation of tumour growth has been observed using a mouse tumour model. We suggest that combined electric field and ultrasound (CEFUS) therapy may provide a novel, drug-free treatment modality for cancer.

Keywords: Electric fields, Ultrasound, Electrochemotherapy, Combined therapy, Cancer treatment, CEFUS

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PII: S0304-3835(04)00743-8

doi:10.1016/j.canlet.2004.09.033

Cancer Letters
Volume 222, Issue 1 , Pages 49-55, 10 May 2005

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