Cancer Letters
Volume 223, Issue 2 , Pages 181-190, 8 June 2005

Chemopreventive and therapeutic effects of curcumin

Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg

Received 28 August 2004; accepted 10 September 2004.

Abstract 

Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. In this review, we describe both properties and mode of action of curcumin on carcinogenesis, gene expression mechanisms and drug metabolism.

Keywords: Chemopreventive agent, Curcumin, Cancer, Apoptosis, Drug metabolism

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PII: S0304-3835(04)00723-2

doi:10.1016/j.canlet.2004.09.041

Cancer Letters
Volume 223, Issue 2 , Pages 181-190, 8 June 2005

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