Cancer Letters
Volume 222, Issue 1 , Pages 119-124, 10 May 2005

Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells

  • Jean L. Lord

      Affiliations

    • Graduate School of Public Health, San Diego State University, San Diego, CA 92182-4162, USA
    • ,
  • Ann de Peyster

      Affiliations

    • Graduate School of Public Health, San Diego State University, San Diego, CA 92182-4162, USA
    • ,
  • P.J.E. Quintana

      Affiliations

    • Graduate School of Public Health, San Diego State University, San Diego, CA 92182-4162, USA
    • ,
  • Robert P. Metzger

      Affiliations

    • Department of Chemistry, San Diego State University, San Diego, CA 92182-1030, USA
    • Corresponding Author InformationCorresponding author. Fax: +1 619 594 4634.

Received 16 March 2004; accepted 2 September 2004.

Abstract 

Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500μM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109±13μM (mean±SEM of y estimate) and 103±9μM, respectively. The IC50 values for pteridine mixtures were similar although 3:1 and 4:1 isoxanthopterin:xanthopterin ratios seemed slightly more cytotoxic than other mixtures. However, ANOVA revealed no statistical differences in the cytotoxicity of mixtures.

Keywords: Xanthopterin, Isoxanthopterin, Pterins, Pteridines, MF-7 cells, Cytotoxicity

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PII: S0304-3835(04)00714-1

doi:10.1016/j.canlet.2004.09.009

Cancer Letters
Volume 222, Issue 1 , Pages 119-124, 10 May 2005

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