Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats

Paragh, György; Fóris, Gabriella; Paragh, György; Seres, Ildikó; Karányi, Zsolt; Fülöp, Péter; Balogh, Zoltán; Kosztáczky, Béla; Teichmann, Farkas; Kertai, Pál

doi:10.1016/j.canlet.2004.09.028

« Previous Next »Cancer Letters
Volume 222, Issue 1 , Pages 17-22, 10 May 2005

Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats

György Paragh
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Gabriella Fóris
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
- Corresponding author. Fax: +36 52 417 385.
György Paragh Jr
- Department of Dermatology, Semmelweis University, Budapest, Hungary
Ildikó Seres
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Zsolt Karányi
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Péter Fülöp
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Zoltán Balogh
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Béla Kosztáczky
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Farkas Teichmann
- First Department of Medicine, University of Debrecen, P.O. Box 19, Debrecen H-4012, Hungary
Pál Kertai
- Institute of Preventive Medicine, Medical and Health Science Center, University of Debrecen, Debrecen H-4012, Hungary

Received 4 March 2004; received in revised form 18 August 2004; accepted 2 September 2004.

Abstract

Rats (FLF1) were pretreated with 2 and 20mg/kg/day fluvastatin (Flu), and after 6 weeks, hepatocellular tumor cells were inoculated under the left renal capsule. At different times, growth and pyruvate kinase (PK) activity of the primary tumors and lymph node metastases were determined. Flu had a dose-dependent inhibitory effect on primary and metastatic tumors, and the inhibitiory effect on growth and PK activity in metastases were higher than in primary tumors. Finally, Flu had an earlier inhibitory effect on the early appeared PK activity in metastases than in primary tumors.