Cancer Letters
Volume 222, Issue 1 , Pages 11-15 , 10 May 2005

Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver

  • Shoji Fukushima

      Affiliations

    • Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6645 3735; fax: +81 6 6646 3093.
    • ,
  • Hideki Wanibuchi

      Affiliations

    • Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    • ,
  • Keiichirou Morimura

      Affiliations

    • Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    • ,
  • Dai Nakae

      Affiliations

    • Department of Pathology, Sasaki Institute, Sasaki Foundation, 2-2 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan
    • ,
  • Hiroyuki Tsuda

      Affiliations

    • Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    • Present address: Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Science, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
    • ,
  • Katsumi Imaida

      Affiliations

    • Onco-Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University, 1750 Ikenobe, Miki-cho, Kagawa 761-0793, Japan
    • ,
  • Tomoyuki Shirai

      Affiliations

    • Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Masae Tatematsu

      Affiliations

    • Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
    • ,
  • Tetsuya Tsukamoto

      Affiliations

    • Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
    • ,
  • Masao Hirose

      Affiliations

    • Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    • ,
  • Fumio Furukawa

      Affiliations

    • Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan

Received 23 April 2004 ,Revised 19 August 2004 ,Accepted 31 August 2004.

References 

  1. Preussmann R. The problem of thresholds in chemical carcinogenesis—some views on theoretical and practical aspects. Cancer Res. Clin. Oncol. 1980;97:1–14
  2. Tomatis L, Huff J, Hertz-Picciotto I, Sandler DP, Bucher J, Boffetta P, et al. Avoided and avoidable risk of cancer. Carcinogenesis. 1997;18:97–105
  3. Gaylor DW. Summary and conclusions. J. Environ. Pathol. Toxicol. 1979;3:179–183
  4. Littlefield NA, Farmer JH, Gaylor DW, Sheldon WG. Effects of dose and time in a long-term, low-dose carcinogenic study. J. Environ. Pathol. Toxicol. 1979;3:17–34
  5. Peto R, Gray R, Brantom P, Grasso P. Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose–response study. Cancer Res. 1991;51:6415–6451
  6. Fukushima H, Wanibuchi K, Morimura M, Wei D, Nakae Y, Konishi H, et al. Lack of a dose–response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine. Jpn. J. Cancer Res. 2002;93:1076–1082
  7. Fukushima H, Wanibuchi K, Morimura M, Wei D, Nakae Y, Konishi H, et al. Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett. 2003;1911:35–40
  8. Williams GM, Iatropoulos MJ, Wang CX, Jeffrey AM, Thompson X, Pittman B, et al. Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. Toxicol. Sci. 1998;45:152–161
  9. Williams GM, Iatropoulos MJ, Jeffrey AM. Mechanistic basis for nonlinearities and thresholds in rat liver carcinogens by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine. Toxicol. Pathol. 2000;28:388–395
  10. Bartsch H, Montesano R. Relevance of nitrosamines to human cancer. Carcinogenesis. 1984;5:1381–1393
  11. Ito N, Tsuda H, Tatematsu M, Inoue T, Tagawa Y, Aoki T, et al. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rat—an approach for a new medium-term bioassay system. Carcinogenesis. 1988;9:387–394
  12. Sato K, Kitahara A, Satoh K, Ishikawa T, Tatematsu M, Ito N. The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann. 1984;75:199–202
  13. Luts WK. Dose–response relationship in chemical carcinogenesis: superposition of different mechanisms of action, resulting in linear–nonlinear curves, practical thresholds, J-shapes. Mutat. Res. 1998;405:117–124
  14. Waddell WJ. Thresholds in chemical carcinogenesis: what are animal experiments telling us?. Toxicol. Pathol. 2003;31:260–262
  15. Fukushima S, Wanibuchi H, Morimura K, Iwai S, Nakae D, Kishida H, et al. Existence of a thresholds for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-pehnolomidazo[4,5-b]pyridine. Toxicol. Sci. 2004;80:109–114
  16. Masumura K, Horigushi M, Nishikawa A, Uehara T, Kanki K, Kanke Y, et al. Low dose genotoxity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice. Mutat. Res. 2003;541:91–102
  17. Hohi M, Morimura K, Wanibuchi H, Wei M, Okochi E, Ushijima T, et al. No observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen. Toxicol. Sci. 2004;80:1–7

PII: S0304-3835(04)00706-2

doi: 10.1016/j.canlet.2004.08.035

Cancer Letters
Volume 222, Issue 1 , Pages 11-15 , 10 May 2005

Article Tools

* Image Usage & Resolution