Cancer Letters
Volume 222, Issue 1 , Pages 107-112 , 10 May 2005

Changes over time in thymidine phosphorylase and dihydropyrimidine dehydrogenase when colon cancer samples are left at room temperature

  • Hideyuki Ishida

      Affiliations

    • Department of Surgery, Osaka Seamen's Insurance Hospital, 1-8-30 Chikukou, Minato-ku, Osaka 552-0021, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6572 5721; fax: +81 6 6573 2531.
    • ,
  • Masayuki Tatsuta

      Affiliations

    • Department of Surgery, Sakai Municipal Hospital, 1-1-1 Minami-Yasui-Cho, Sakai, Osaka 591-0064, Japan
    • ,
  • Hirofumi Yamamoto

      Affiliations

    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Hiroshi Furukawa

      Affiliations

    • Department of Surgery, Sakai Municipal Hospital, 1-1-1 Minami-Yasui-Cho, Sakai, Osaka 591-0064, Japan
    • ,
  • Seizou Masutani

      Affiliations

    • Department of Surgery, Sakai Municipal Hospital, 1-1-1 Minami-Yasui-Cho, Sakai, Osaka 591-0064, Japan
    • ,
  • Hiroyoshi Takemoto

      Affiliations

    • Department of Surgery, Sakai Municipal Hospital, 1-1-1 Minami-Yasui-Cho, Sakai, Osaka 591-0064, Japan
    • ,
  • Satoru Munakata

      Affiliations

    • Department of Pathology, Sakai Municipal Hospital, Osaka, Japan
    • ,
  • Hideaki Miwa

      Affiliations

    • Department of Pathology, Izumiotsu Municipal Hospital, Osaka, Japan
    • ,
  • Mitsugu Sekimoto

      Affiliations

    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Morito Monden

      Affiliations

    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan

Received 29 June 2004 ,Revised 23 August 2004 ,Accepted 31 August 2004.

References 

  1. Ishikawa T, Sekiguchi F, Fukase Y, Sawada N, Ishitsuka H. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res. 1998;58:685–690
  2. Etienne MC, Cheradame S, Fischel JL, Formento P, Dassonville O, Renee N, et al. Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity. J. Clin. Oncol. 1995;13:1663–1670
  3. Nishida M, Hino A, Mori K, Matsumoto T, Yoshikubo T, Ishitsuka H. Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues. Biol. Pharm. Bull. 1996;19:1407–1411
  4. Mori K, Hasegawa M, Nishida M, Toma H, Fukuda M, Kubota T, et al. Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. Int. J. Oncol. 2000;17:33–38
  5. Kono T, Nishida M, Inagaki N, Tanaka Y, Yoneda M, Kasai S. Development and characterization of 1C6-203, a new monoclonal antibody specific to human thymidine phosphorylase. J. Histochem. Cytochem. 2001;49:131–137
  6. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S. Angiogenic factor. Nature. 1992;356:668
  7. Takabayashi Y, Miyadera K, Akiyama S, Hokita S, Yamada K, Akiba S, et al. Expression of thymidine phosphorylase in human gastric carcinoma. Jpn. J. Cancer Res. 1996;87:288–295
  8. Takabayashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, et al. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J. Natl Cancer Inst. 1996;88:1110–1117
  9. Maeda K, Chung YS, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, et al. Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br. J. Cancer. 1996;73:884–888
  10. Metzger R, Danenberg K, Leichman CG, Salonga D, Schwartz EL, Wadler S, et al. High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. Clin. Cancer Res. 1998;4:2371–2376

PII: S0304-3835(04)00705-0

doi: 10.1016/j.canlet.2004.08.036

Cancer Letters
Volume 222, Issue 1 , Pages 107-112 , 10 May 2005

Article Tools

* Image Usage & Resolution