Cancer Letters
Volume 220, Issue 1 , Pages 115-120 , 18 March 2005

Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development

  • Birgit Zirn

      Affiliations

    • Theodor-Boveri-Institut fuer Biowissenschaften, Physiologische Chemie I, Am Hubland, D-97074 Wuerzburg, Germany
    • ,
  • Stefanie Wittmann

      Affiliations

    • Theodor-Boveri-Institut fuer Biowissenschaften, Physiologische Chemie I, Am Hubland, D-97074 Wuerzburg, Germany
    • ,
  • Norbert Graf

      Affiliations

    • Children's Hospital, Department of Paediatric Oncology and Haematology, University of the Saarland, D-66421 Homburg/Saar, Germany
    • ,
  • Manfred Gessler

      Affiliations

    • Theodor-Boveri-Institut fuer Biowissenschaften, Physiologische Chemie I, Am Hubland, D-97074 Wuerzburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 931 888 4159; fax: +49 931 888 7038.

Received 6 July 2004 ,Revised 2 August 2004 ,Accepted 2 August 2004.

References 

  1. Gessler M, Konig A, Arden K, Grundy P, Orkin S, Sallan S, et al. Infrequent mutation of the WT1 gene in 77 Wilms' tumors. Hum. Mutat. 1994;3:212–222
  2. Maiti S, Alam R, Amos CI, Huff V. Frequent association of beta-catenin and WT1 mutations in Wilms tumors. Cancer Res. 2000;60:6288–6292
  3. Varanasi R, Bardeesy N, Ghahremani M, Petruzzi MJ, Nowak N, Adam MA, et al. Fine structure analysis of the WT1 gene in sporadic Wilms tumors. Proc. Natl Acad. Sci. USA. 1994;91:3554–3558
  4. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GA. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990;343:774–778
  5. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms’ tumor locus. Cell. 1990;60:509–520
  6. Hastie ND. Life, sex, and WT1 isoforms—three amino acids can make all the difference. Cell. 2001;106:391–394
  7. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281:1509–1512
  8. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398:422–426
  9. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997;275:1787–1790
  10. Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science. 1997;275:1790–1792
  11. Polakis P. Wnt signaling and cancer. Genes Dev. 2000;14:1837–1851
  12. Huff V. Wilms tumor genetics. Am. J. Med. Genet. 1998;79:260–267
  13. Koesters R, Niggli F, von Knebel Doeberitz M, Stallmach T. Nuclear accumulation of beta-catenin protein in Wilms’ tumours. J. Pathol. 2003;199:68–76
  14. Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature. 2003;422:905–909
  15. Greaves S. Small changes in Wnt signalling. Nat. Cell Biol. 2003;5:387
  16. Klamt B, Schulze M, Thate C, Mares J, Goetz P, Kodet R, et al. Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters. Genes Chromosomes Cancer. 1998;22:287–294
  17. Modrek B, Lee C. A genomic view of alternative splicing. Nat. Genet. 2002;30:13–19

PII: S0304-3835(04)00620-2

doi: 10.1016/j.canlet.2004.08.001

Cancer Letters
Volume 220, Issue 1 , Pages 115-120 , 18 March 2005

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