Cancer Letters
Volume 220, Issue 1 , Pages 29-35, 18 March 2005

Antimutagenicity of selenium-enriched rice on mice exposure to cyclophosphamide and mitomycin C

  • Qiuhui Hu

      Affiliations

    • Key Laboratory of Food Processing and Quality Control of Agriculture Ministry of China, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +86-25-8439-5618; fax: +86-25-8439-6431.
    • ,
  • Juan Xu

      Affiliations

    • Key Laboratory of Food Processing and Quality Control of Agriculture Ministry of China, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
    • Department of Biology, Changshu Institute of Science and Technology, Changshu 215500, People's Republic of China
    • ,
  • Licheng Chen

      Affiliations

    • Jiangsu Branch, China National Import and Export Commodities Inspection Corporation, Nanjing 210009, People's Republic of China

Received 19 April 2004; received in revised form 25 June 2004; accepted 28 June 2004.

Abstract 

The in vivo antimutagenicity of Se-enriched rice was evaluated by bone marrow micronucleus and testicle chromosomal aberrations assay in mice exposed to cyclophosphamide (CP) and mitomycin C (MMC). Regular rice did not alter the occurrence of chemical-induced mutation. However, the addition of Se-enriched rice or selenite significantly inhibited the incidence of CP-induced micronuclei and MMC-induced chromosomal aberration in mice and the effect was dose-dependent. Providing selenite or Se-enriched rice also significantly increased the activity of glutathione peroxidase in liver and the selenium concentration in blood compared to regular rice. No significant differences were found in mice body weight gain. These results revealed the antimutagenic potential of Se-enriched rice against chemical-induced mutation.

Keywords: Se-enriched rice, Antimutagenicity, Bone marrow micronucleus, Testicle chromosomal aberrations

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PII: S0304-3835(04)00507-5

doi:10.1016/j.canlet.2004.06.041

Cancer Letters
Volume 220, Issue 1 , Pages 29-35, 18 March 2005

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