Cancer Letters
Volume 220, Issue 1 , Pages 11-19 , 18 March 2005

Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells

  • Seong Gyu Ko

      Affiliations

    • Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
    • Department of Internal Medicine, College of Oriental Medicine, Sangji University, Wonju-Si, Kangwon Province 220-130, South Korea
    • ,
  • Hwang-Phill Kim

      Affiliations

    • Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
    • ,
  • Dong-Hoon Jin

      Affiliations

    • Department of Life Science, Sogang University, Seoul, South Korea
    • ,
  • Hyun-Su Bae

      Affiliations

    • Department of Internal Medicine, College of Oriental Medicine, Sangji University, Wonju-Si, Kangwon Province 220-130, South Korea
    • ,
  • Sung Hoon Kim

      Affiliations

    • Graduate School of East–West Medical Science, Kyunghee University, Seoul, South Korea
    • ,
  • Chong-Hyeong Park

      Affiliations

    • Department of Internal medicine, College of Oriental Medicine, Kyungwon University, Seoul, South Korea
    • ,
  • Jung Weon Lee

      Affiliations

    • Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
    • Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
    • Corresponding Author InformationCorresponding author. Address: Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea. Tel.: +82-2-3668-7030; fax: +82-2-766-4487.

Received 15 November 2003 ,Revised 14 June 2004 ,Accepted 15 June 2004.

References 

  1. Robles M, Aregullin M, West J, Rodriguez E. Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Med. 1995;61:199–203
  2. Lee MG, Lee KT, Chi SG, Park JH. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Biol. Pharm. Bull. 2001;24:303–306
  3. Mori H, Kawamori T, Tanaka T, Ohnishi M, Yamahara J. Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 1994;83:171–175
  4. Jeong SJ, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, et al. Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 2002;187:129–133
  5. Obaya AJ, Sedivy JM. Regulation of cyclin-Cdk activity in mammalian cells. Cell Mol. Life Sci. 2002;59:126–142
  6. Assoian RK, Zhu X. Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression. Curr. Opin. Cell Biol. 1997;9:93–98
  7. Assoian RK, Schwartz MA. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 2001;11:48–53
  8. Danen EH, Yamada KM. Fibronectin, integrins, and growth control. J. Cell Physiol. 2001;189:1–13
  9. Juliano RL. Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu. Rev. Pharmacol. Toxicol. 2002;42:283–323
  10. Huang S, Ingber DE. A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent. Exp. Cell Res. 2002;275:255–264
  11. Niculescu AB, Chen X, Smeets M, Hengst L, Prives C, Reed SI. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell Biol. 1998;18:629–643
  12. Smits VA, Klompmaker R, Vallenius T, Rijksen G, Makela TP, Medema RH. p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint. J. Biol. Chem. 2000;275:30638–30643
  13. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998;282:1497–1501
  14. Lee JW, Juliano RL. alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway. Mol. Biol. Cell. 2000;11:1973–1987
  15. Choi JH, Ha J, Park JH, Lee JY, Lee YS, Park HJ, et al. Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols. Jpn. J. Cancer Res. 2002;93:1327–1333
  16. Goodarzi AA, Block WD, Lees-Miller SP. The role of ATM and ATR in DNA damage-induced cell cycle control. Prog. Cell Cycle Res. 2003;5:393–411
  17. Pietenpol JA, Stewart ZA. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology. 2002;181-182:475–481
  18. Innocente SA, Abrahamson JL, Cogswell JP, Lee JM. p53 regulates a G2 checkpoint through cyclin B1. Proc. Natl Acad. Sci. USA. 1999;96:2147–2152
  19. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature. 1999;401:616–620
  20. Wang XW, Zhan Q, Coursen JD, Khan MA, Kontny HU, Yu L, et al. GADD45 induction of a G2/M cell cycle checkpoint. Proc. Natl Acad. Sci. USA. 1999;96:3706–3711
  21. Sedlak TW, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl Acad. Sci. USA. 1995;92:7834–7838
  22. Basu A, Haldar S. The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death. Mol. Hum. Reprod. 1998;4:1099–1109
  23. Brambilla C, Fievet F, Jeanmart M, de Fraipont F, Lantuejoul S, Frappat V, et al. Early detection of lung cancer: role of biomarkers. Eur. Respir. J. Suppl. 2003;39:36s–44s
  24. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and Bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799–1805
  25. Miyashita T, Harigai M, Hanada M, Reed JC. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res. 1994;54:3131–3135
  26. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene. Cell. 1995;80:293–299
  27. Sionov RV, Haupt Y. The cellular response to p53: the decision between life and death. Oncogene. 1999;18:6145–6157
  28. Philchenkov AA. Caspases as regulators of apoptosis and other cell functions. Biochemistry (Mosc). 2003;68:365–376
  29. Wu MS, Chen CJ, Lin JT. Genetic alterations and polymorphisms in gastric cancer. J. Formos. Med. Assoc. 2003;102:447–458

PII: S0304-3835(04)00475-6

doi: 10.1016/j.canlet.2004.06.026

Cancer Letters
Volume 220, Issue 1 , Pages 11-19 , 18 March 2005

Article Tools

* Image Usage & Resolution