Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells

Ko, Seong Gyu; Kim, Hwang-Phill; Jin, Dong-Hoon; Bae, Hyun-Su; Kim, Sung Hoon; Park, Chong-Hyeong; Lee, Jung Weon

doi:10.1016/j.canlet.2004.06.026

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Volume 220, Issue 1 , Pages 11-19, 18 March 2005

Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells

Seong Gyu Ko
- Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
- Department of Internal Medicine, College of Oriental Medicine, Sangji University, Wonju-Si, Kangwon Province 220-130, South Korea
Hwang-Phill Kim
- Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
Dong-Hoon Jin
- Department of Life Science, Sogang University, Seoul, South Korea
Hyun-Su Bae
- Department of Internal Medicine, College of Oriental Medicine, Sangji University, Wonju-Si, Kangwon Province 220-130, South Korea
Sung Hoon Kim
- Graduate School of East–West Medical Science, Kyunghee University, Seoul, South Korea
Chong-Hyeong Park
- Department of Internal medicine, College of Oriental Medicine, Kyungwon University, Seoul, South Korea
Jung Weon Lee
- Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
- Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, Seoul 110-799, South Korea
- Corresponding author. Address: Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea. Tel.: +82-2-3668-7030; fax: +82-2-766-4487.

Received 15 November 2003; received in revised form 14 June 2004; accepted 15 June 2004.

Absract

The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy.

Keywords: Saussurea lappa, Apoptosis, Gastric cancer, p53, Growth arrest, ATM/ATR