Cancer Letters
Volume 208, Issue 2 , Pages 179-186 , 28 May 2004

In vivo reversal of doxorubicin resistance by (−)-epigallocatechin gallate in a solid human carcinoma xenograft

Received 22 September 2003 ,Revised 27 January 2004 ,Accepted 28 January 2004.

References 

  1. Krishna R, Mayer LD. Multidrug resistance (MDR) in cancer Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci. 2000;11:265–283
  2. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 1993;62:385–427
  3. Zhu A, Wang XY, Guo ZQ. Study of tea polyphenol as a reversal agent for carcinoma cell lines' multidrug resistance (study of TP as a MDR reversal agent). Nucl. Med. Biol. 2001;28:735–740
  4. Wang ZY, Cheng SJ, Zhou ZC, Athar M, Khan WA, Bickers DR, et al. Antimutagenic activity of green tea polyphenols. Mutat. Res. 1989;223:273–285
  5. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J. Cell. Biochem. 1995;22:169–180
  6. Chen ZP, Schell JB, Ho CT, Chen KY. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Lett. 1998;129:173–179
  7. Uesato S, Kitagawa Y, Kamishimoto M, Kumagai A, Hori H, Nagasawa H. Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells. Cancer Lett. 2001;170:41–44
  8. Lin YL, Juan IM, Chen YL, Liang YC, Lin JK. Composition of polyphenols in fresh tea leaves and associations of their oxygen-radical-absorbing capacity with antiproliferative actions in fibroblast cells. J. Agri. Food Chem. 1996;44:1387–1394
  9. Sadzuka Y, Sugiyama T, Sonobe T. Efficacies of tea component on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol. Lett. 2000;114:155–162
  10. Gerd S, Manfred V. Green tea catechins (EGCG and EGC) have modulating effects on the activity of DOX in drug-resistance cell lines. Anticancer Drugs. 1997;8:265–268
  11. Wei DZ, Mei YY, Liu JW. Quantification of doxorubicin and validation of reversal effect of tea polyphenols on multdrug resistance in human carcinoma cells. Biotechnol. Lett. 2003;25:291–294
  12. Mei YY, Wei DZ, Liu JW. Reversal of cancer multidrug resistance by tea polyphenol in KB cells. J. Chemother. 2003;15:251–256
  13. Liu JD, Chen SH, Lin CL, Tsai SH, Liang YC. Inhibition of melanoma growth and metastasis by combination with (−)-epigallocatechin-3-gallate and dacarbazine in mice. J. Cell. Biochem. 2001;83:631–642
  14. Abolhoda A, Wilson AE, Ross H, Danenberg PV, Burt M, Scotto KW. Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin. Clin. Cancer Res. 1999;5:3352–3356
  15. Brigui I, Djavanbakht-Samani T, Jolles B, Pigaglio S, Laigle A. Minimally modified phosphodiester antisense oligodeoxyribonucleotide directed against the multidrug resistance gene mdr1. Biochem. Pharmacol. 2003;65:747–754
  16. Dolci ED, Abramson R, Xuan Y, Siegfried J, Yuenger KA, Yassa DS, et al. Anomalous expression of P-glycoprotein in highly drug-resistant human KB cells. Int. J. Cancer. 1993;54:302–308
  17. Pierre A, Leonce S, Perez V, Atassi G. Circumvention of P-glycoprotein-mediated multidrug resistance by S16020-2: kinetics of uptake and efflux in sensitive and resistant cell lines. Cancer Chemother. Pharmacol. 1998;42:454–460
  18. Boesch D, Gaveriaux C, Jachez B, Manzanedo AP, Bollinger P, Loor F. In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res. 1991;51:4226–4233
  19. Jodoin J, Demeule M, Beliveau R. Inhibition of the mutldrug resistance P-glycoprotein activity by green tea polyphenols. Biochim. Biophys. Acta. 2002;1542:149–159

PII: S0304-3835(04)00137-5

doi: 10.1016/j.canlet.2004.01.033

Cancer Letters
Volume 208, Issue 2 , Pages 179-186 , 28 May 2004

Article Tools

* Image Usage & Resolution