Cancer Letters
Volume 208, Issue 2 , Pages 171-178 , 28 May 2004

VR-3848, a novel peptide derived from Euphobiaceae, induces mitochondria-dependent apoptosis in human leukemia cells

  • Wanlaya Uthaisang

      Affiliations

    • Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    • Institute of Environmental Medicine, Division of Toxicology, Nobels väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
    • ,
  • Vichai Reutrakul

      Affiliations

    • Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    • ,
  • Chongkon Krachangchaeng

      Affiliations

    • Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    • ,
  • Prapon Wilairat

      Affiliations

    • Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    • ,
  • Bengt Fadeel

      Affiliations

    • Institute of Environmental Medicine, Division of Toxicology, Nobels väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46-8-728-7556; fax: +46-8-32-90-41

Received 14 November 2003 ,Revised 19 December 2003 ,Accepted 21 January 2004.

References 

  1. R. Pootrakronchai, Apoptosis induction by VR-3848 isolated from Euphobiaceae in a human lung cancer cell line, Master of Science thesis (Toxicology), Mahidol University, Bangkok, Thailand, 2000.
  2. Makin G, Dive C. Apoptosis and cancer chemotherapy. Trends Cell Biol. 2001;11:22–26
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  10. Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, et al.  Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J. Biol. Chem. 2002;277:20301–20308
  11. Fadeel B, Zhivotovsky B, Orrenius S. All along the watchtower: on the regulation of apoptosis regulators. Fed. Am. Soc. Exp. Biol. J. 1999;13:1647–1657
  12. Bantel H, Engels IH, Voelter W, Schulze-Osthoff K, Wesselborg S. Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res. 1999;59:2083–2090
  13. Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, et al.  Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene. 2002;21:1242–1250
  14. Okada S, Li Q, Whitin JC, Clayberger C, Krensky AM. Intracellular mediators of granulysin-induced cell death. J. Immunol. 2003;171:2556–2562

PII: S0304-3835(04)00103-X

doi: 10.1016/j.canlet.2004.01.024

Cancer Letters
Volume 208, Issue 2 , Pages 171-178 , 28 May 2004

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