Cancer Letters
Volume 210, Issue 1 , Pages 81-84, 8 July 2004

Expression of prostaglandin D2 receptors DP1 and DP2 by human colorectal cancer cells

Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK

Received 9 January 2004; accepted 13 January 2004.

Abstract 

The expression and function of prostaglandin (PG) D2 DP receptors during colorectal carcinogenesis has not been elucidated. Therefore, we studied expression of DP1 and DP2 receptors by reverse transcription-polymerase chain reaction analysis of receptor mRNA levels in five human colorectal cancer cell lines (HT-29, HCA-7, HCT116, SW480 and SW48) and VACO-235 human colorectal adenoma cells. DP1 receptor transcripts were present only in HT-29 cells. In addition, none of the human colorectal epithelial cell lines tested expressed DP2 receptor mRNA. Therefore, PGD2 is unlikely to have direct activity on neoplastic colorectal epithelial cells via cell surface DP receptors.

Keywords:  Colorectal cancer, DP receptor, Non-steroidal anti-inflammatory drug, Prostaglandin

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PII: S0304-3835(04)00060-6

doi:10.1016/j.canlet.2004.01.015

Cancer Letters
Volume 210, Issue 1 , Pages 81-84, 8 July 2004

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